{"id":"W2595611953","doi":"10.1182/blood.v128.22.489.489","title":"Efficacy of Daratumumab, Lenalidomide and Dexamethasone Versus Lenalidomide and Dexamethasone Alone for Relapsed or Refractory Multiple Myeloma Among Patients with 1 to 3 Prior Lines of Therapy Based on Previous Treatment Exposure: Updated Analysis of Pollux","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Québec; University of British Columbia","funders":"","keywords":"Lenalidomide; Daratumumab; Dexamethasone; Medicine; Internal medicine; Interim analysis; Clinical endpoint; Multiple myeloma; Refractory (planetary science); Gastroenterology; Intention-to-treat analysis; Oncology; Surgery; Randomized controlled trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004416053,0.0004843444,0.002304367,0.0008908602,0.0002241905,0.001195008,0.0009777155,0.0006248933,0.002390204],"category_scores_gemma":[0.004829398,0.0003899762,0.004928389,0.001143904,0.0002600433,0.0006946225,0.0005493789,0.00104636,0.0002741072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009426003,"about_ca_system_score_gemma":0.0006553696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001485643,"about_ca_topic_score_gemma":0.003180153,"domain_scores_codex":[0.997837,0.0009981976,0.0002710746,0.0004254519,0.0003508874,0.0001173109],"domain_scores_gemma":[0.9956163,0.001843843,0.001505005,0.0003864939,0.0003155853,0.0003327909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.336527,0.001397864,0.30733,0.00619994,0.06816706,0.00038106,0.0004869594,0.002022801,0.007020389,0.000299928,0.006000842,0.2641661],"study_design_scores_gemma":[0.06413358,0.04333902,0.802024,0.0008293848,0.06841897,0.001288554,0.0001812733,0.001555027,0.002494752,0.0004152789,0.01519867,0.0001215747],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331718,0.05848939,0.0005684648,0.0005850392,0.0001506898,0.0004414812,0.004269497,0.00004523398,0.002278317],"genre_scores_gemma":[0.9861902,0.0077955,0.0005493475,0.0006914085,0.0002094768,0.0001956231,0.003769084,0.0000192137,0.0005800128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004416053,"threshold_uncertainty_score":0.02335459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03217945903125362,"score_gpt":0.2985486450783643,"score_spread":0.2663691860471106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}