{"id":"W2595624457","doi":"10.1016/j.biomaterials.2017.03.022","title":"Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages","year":2017,"lang":"en","type":"article","venue":"Biomaterials","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Polytechnique Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"Chitosan; Inflammasome; Paracrine signalling; Cell biology; Autophagy; Cytokine; CXCL10; Acetylation; Immune system; Lysosome; Chemistry; Chemokine; Biology; Biochemistry; Immunology; Receptor; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117311,0.0003671735,0.000181613,0.000214461,0.00009399779,0.0002139702,0.0001037093,0.0002479481,0.0006670824],"category_scores_gemma":[0.0001105023,0.0001176793,0.0002449476,0.0001645965,0.0001512193,0.0001681951,0.0001682613,0.0002847141,0.0001319273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002178977,"about_ca_system_score_gemma":0.0001511268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002854953,"about_ca_topic_score_gemma":0.0005714064,"domain_scores_codex":[0.9999061,0.00001475748,0.000008935304,0.00001445615,0.00002973724,0.00002607122],"domain_scores_gemma":[0.9999303,0.00000865797,0.00002878832,0.000006576813,0.00000936022,0.00001625295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000720923,0.000008015666,0.00009613347,0.00001729344,0.000002862842,0.00002190813,0.00000371562,0.00002515936,0.9994061,0.000009902331,0.000005848881,0.0003310337],"study_design_scores_gemma":[0.000009648715,0.0003862413,0.003309787,0.000004243117,0.00001638343,0.0001703717,0.00001690554,0.00018706,0.9954265,0.00001334483,0.0004566092,0.000003023681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978449,0.0006737286,0.0008560371,0.0000293553,0.000007251244,0.00001712793,0.0001260381,0.00001595527,0.0004294922],"genre_scores_gemma":[0.9968693,0.0007273728,0.001248172,0.00006161244,0.000006026476,0.00002552696,0.0003125302,0.000006482567,0.0007429784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006670824,"threshold_uncertainty_score":0.002231658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03401591884893723,"score_gpt":0.3343424555197027,"score_spread":0.3003265366707654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}