{"id":"W2595666038","doi":"10.18632/oncotarget.16376","title":"Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Uehara Memorial Foundation","keywords":"Camptothecin; Ubiquitin; Proteasome; Topoisomerase; Ku80; Biology; Serine; Cell biology; DNA; Chemistry; Biochemistry; Phosphorylation; DNA-binding protein; Transcription factor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071776,0.0002184461,0.0002380848,0.0003378921,0.0003078103,0.0006454195,0.0001550782,0.0002503345,0.002529378],"category_scores_gemma":[0.0002369475,0.0001584408,0.0002217783,0.0001785862,0.0002329008,0.000218598,0.0001608925,0.0005112077,0.0007528942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005127093,"about_ca_system_score_gemma":0.0002617143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001288959,"about_ca_topic_score_gemma":0.001279797,"domain_scores_codex":[0.9998674,0.000008799977,0.000009978871,0.00004053993,0.00003995773,0.00003330499],"domain_scores_gemma":[0.999793,0.00001843575,0.0001019877,0.00001472997,0.00003256155,0.00003927864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003711551,0.00007327432,0.006555877,0.0001004423,0.00002120439,0.0004796665,0.00005372113,0.0000968953,0.9815668,0.0003099644,0.001229398,0.009141698],"study_design_scores_gemma":[0.00008654511,0.0004901742,0.3275957,0.00006989972,0.00008469944,0.005074851,0.0003551477,0.003389068,0.6495767,0.0005599914,0.01267413,0.00004299265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749829,0.01480485,0.001913499,0.0007972933,0.0001260802,0.00005653174,0.0009785547,0.0001835286,0.006156659],"genre_scores_gemma":[0.9906696,0.003867842,0.0006157213,0.0001395164,0.00004177512,0.00002397795,0.0005801104,0.00002030612,0.004040997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002529378,"threshold_uncertainty_score":0.008461654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069350677283209,"score_gpt":0.2501295163234817,"score_spread":0.2394360095506496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}