{"id":"W2595789214","doi":"10.1111/hepr.12893","title":"Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug‐induced liver injury by direct acting antivirals","year":2017,"lang":"en","type":"article","venue":"Hepatology Research","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alberta Innovates - Health Solutions","keywords":"Internal medicine; Alanine transaminase; Medicine; Liver injury; Elevated transaminases; Gastroenterology; SOD2; Transaminase; Immunology; Biology; Superoxide dismutase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002869742,0.0003828089,0.0004744362,0.0005801915,0.0002799928,0.0004027923,0.0001517706,0.0003106037,0.0009929853],"category_scores_gemma":[0.000902977,0.0001566936,0.0002315177,0.0004006712,0.000220129,0.0002710241,0.0002291488,0.0003494774,0.0001778321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001526098,"about_ca_system_score_gemma":0.0001350857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003292694,"about_ca_topic_score_gemma":0.0005371847,"domain_scores_codex":[0.9997727,0.00005947684,0.00003819834,0.00004694383,0.00004270389,0.00003994613],"domain_scores_gemma":[0.9990182,0.0001758797,0.0005372579,0.00004085411,0.00007496748,0.0001529493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005880977,0.00005492722,0.9946037,0.00001314656,0.00002434275,0.0001734267,0.00002282221,0.00002825492,0.002342998,0.000006625775,0.0000209389,0.002120625],"study_design_scores_gemma":[0.00002168618,0.0009990545,0.996525,0.000007273969,0.00003109848,0.001219885,0.0000729839,0.0001937957,0.0007966202,0.00001329013,0.000116373,0.000002922286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992293,0.0004261969,0.00008418976,0.00001192408,0.000003106408,0.00001040895,0.00004341138,0.000004163832,0.0001873281],"genre_scores_gemma":[0.9996532,0.00008321025,0.0001036333,0.00001195337,0.000007512628,0.000005534881,0.00007590598,6.37311e-7,0.00005843784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009929853,"threshold_uncertainty_score":0.003321886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1994002820751904,"score_gpt":0.4715173962768189,"score_spread":0.2721171142016285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}