{"id":"W2595789214","doi":"10.1111/hepr.12893","title":"Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug‐induced liver injury by direct acting antivirals","year":2017,"lang":"en","type":"article","venue":"Hepatology Research","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alberta Innovates - Health Solutions","keywords":"Internal medicine; Alanine transaminase; Medicine; Liver injury; Elevated transaminases; Gastroenterology; SOD2; Transaminase; Immunology; Biology; Superoxide dismutase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.003218826,0.0003247011,0.0005264917,0.0004745858,0.004054818,0.0001518307,0.0004921883,0.001084657,0.00009853194],"category_scores_gemma":[0.001819824,0.0003323015,0.0001549648,0.0001954028,0.0005322814,0.0004764716,0.0002771686,0.001698564,0.00002976397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081583,"about_ca_system_score_gemma":0.0002648614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002130221,"about_ca_topic_score_gemma":0.0002000645,"domain_scores_codex":[0.9958775,0.00142423,0.0003931091,0.0008776503,0.0002785038,0.001149032],"domain_scores_gemma":[0.9955961,0.00287194,0.0004392853,0.0004410123,0.0003325759,0.0003191345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.021012,0.001014657,0.4897215,0.001149538,0.0007857008,0.0000494524,0.002735687,0.000004966534,0.2839711,0.0003137123,0.1076819,0.0915598],"study_design_scores_gemma":[0.007062875,0.00155557,0.01169456,0.00008540029,0.000246409,0.00001915847,0.001273484,0.009461169,0.8584324,0.00131745,0.1081388,0.0007127791],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856653,0.0002265382,0.0003056305,0.001520904,0.00243134,0.003843954,0.0008004714,0.0001081245,0.005097714],"genre_scores_gemma":[0.9944046,0.0003675534,0.0002053433,0.0002407028,0.0005994268,0.001477808,0.00005065911,0.00005967591,0.002594252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5744613,"threshold_uncertainty_score":0.9999129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1994002820751904,"score_gpt":0.4715173962768189,"score_spread":0.2721171142016285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}