{"id":"W2595803915","doi":"10.1016/j.bmc.2017.02.068","title":"Covalently linked kanamycin – Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Israel Science Foundation; Ministry of Science, Technology and Space; Israel Academy of Sciences and Humanities; McGill University; University of Notre Dame","keywords":"Chemistry; Ciprofloxacin; Kanamycin; Antibiotics; Covalent bond; Antibiotic resistance; Microbiology; Antibacterial agent; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004080683,0.0005064136,0.0005083752,0.00003367943,0.0004772812,0.0002070777,0.001391962,0.000382737,0.0007841377],"category_scores_gemma":[0.001626646,0.0004952686,0.0001660665,0.00008963134,0.0003748387,0.00001799922,0.0004857056,0.0002910714,0.0002058809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038763,"about_ca_system_score_gemma":0.0004446233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002592785,"about_ca_topic_score_gemma":0.00002895089,"domain_scores_codex":[0.9970511,0.00004434114,0.0006147671,0.001057749,0.0005070113,0.0007250468],"domain_scores_gemma":[0.9967048,0.00002148056,0.0004357544,0.00220788,0.000226594,0.0004034451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007802526,0.00008105444,0.003292236,0.0001873673,0.00009208194,0.0001275201,0.00002924687,1.44338e-7,0.9677588,0.00001943874,0.0272091,0.0004227132],"study_design_scores_gemma":[0.001187975,0.0001680189,0.0180838,0.0002671788,0.00007135564,0.0000683213,0.00006025119,0.000002073966,0.8686412,0.00004268467,0.1108244,0.0005827273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903846,0.0003865612,0.0002864325,0.001481305,0.0009162545,0.0003820109,0.0001490119,0.00005266241,0.005961162],"genre_scores_gemma":[0.9796053,0.0002140062,0.00113077,0.0006190366,0.002532532,0.000003764199,0.0003037429,0.00008988936,0.01550093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09911767,"threshold_uncertainty_score":0.9997499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107818197998659,"score_gpt":0.2648123732586032,"score_spread":0.2540305534587373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}