{"id":"W2595865619","doi":"10.1182/blood.v128.22.719.719","title":"Antiphospholipid Syndrome (APS) Patient Plasmas Consistently Activate Complement: A Novel Approach to Detecting a Pathogenic Mechanism for APS","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Complement system; Antiphospholipid syndrome; Alternative complement pathway; Lupus anticoagulant; Complement membrane attack complex; Immunology; Immune system; Systemic lupus erythematosus; Medicine; Thrombosis; Venous thrombosis; Factor H; Complement (music); Antibody; Internal medicine; Biology; Disease; Biochemistry; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003666098,0.0003161375,0.0002159616,0.0003906566,0.0001385394,0.0002921893,0.0002151742,0.0004557486,0.0009713415],"category_scores_gemma":[0.0002995207,0.0001510267,0.0001999056,0.0002124573,0.0001906804,0.0002335688,0.0002775122,0.0004436295,0.0001646765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001621642,"about_ca_system_score_gemma":0.0001009653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000163701,"about_ca_topic_score_gemma":0.0002326673,"domain_scores_codex":[0.9997112,0.000105957,0.00002212434,0.00005458591,0.00006695261,0.00003911622],"domain_scores_gemma":[0.9998413,0.00005784772,0.0000334458,0.0000170701,0.0000313942,0.00001882805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005334896,0.00007779978,0.003855038,0.00005987834,0.00001652125,0.0001213819,0.0000287683,0.00002556991,0.9922165,0.00004769699,0.00003010226,0.002987196],"study_design_scores_gemma":[0.00007838271,0.003130482,0.05963158,0.00001714018,0.00007933472,0.00286309,0.0001016526,0.001132557,0.9316029,0.0001514452,0.001198485,0.00001300047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956881,0.001243194,0.0024879,0.00004522663,0.00001499235,0.00003134894,0.00006605983,0.0000219915,0.0004012094],"genre_scores_gemma":[0.9942709,0.0005312898,0.004473933,0.00004540103,0.00001785174,0.00003566185,0.0001758972,0.000003005027,0.0004460304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009713415,"threshold_uncertainty_score":0.003249466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04161488049643803,"score_gpt":0.2723220952765087,"score_spread":0.2307072147800707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}