{"id":"W2595873267","doi":"10.1161/atvb.32.suppl_1.a67","title":"Abstract 67: Phase I Safety, Pharmacokinetic, and Pharmacodynamic Results for ALN-PCS, a Novel RNAi Therapeutic for the Treatment of Hypercholesterolemia","year":2012,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kimberly-Clark (Canada)","funders":"","keywords":"PCSK9; Kexin; LDL receptor; Pharmacology; Pharmacodynamics; Pharmacokinetics; Proprotein convertase; Tolerability; Medicine; Internal medicine; Cholesterol; Endocrinology; Lipoprotein; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000639217,0.001051608,0.001015304,0.0004133376,0.0002829099,0.0006621946,0.0004526845,0.0009431855,0.003801772],"category_scores_gemma":[0.0004245212,0.0003032471,0.0008004481,0.0002163327,0.0005397985,0.0004922717,0.0001497189,0.00205163,0.00105932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005299927,"about_ca_system_score_gemma":0.001063083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216433,"about_ca_topic_score_gemma":0.001641089,"domain_scores_codex":[0.9997312,0.00008562201,0.00001568226,0.00004896363,0.00004875247,0.00006974177],"domain_scores_gemma":[0.9996864,0.00004673983,0.00006889817,0.00003405701,0.00003885362,0.0001250979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3349981,0.07130083,0.003402492,0.0009974129,0.00117073,0.0005067847,0.0002636478,0.002692879,0.4435288,0.0006060572,0.01056934,0.129963],"study_design_scores_gemma":[0.1645035,0.7191268,0.01349693,0.00005039774,0.0007822888,0.0005632291,0.00007197166,0.002576435,0.08879569,0.0003413233,0.009629845,0.00006168016],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877982,0.001995273,0.002231815,0.0004737705,0.0001457081,0.001909109,0.002291954,0.000357628,0.002796689],"genre_scores_gemma":[0.9805516,0.001735642,0.003018952,0.0009501714,0.000193032,0.001573069,0.004642807,0.000111361,0.007223489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003801772,"threshold_uncertainty_score":0.01271814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0812440706305932,"score_gpt":0.3733087801728956,"score_spread":0.2920647095423025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}