{"id":"W2595981193","doi":"10.17760/d10016867","title":"The major histocompatibility complex in mouse embryos and embryonic stem cells","year":2008,"lang":"en","type":"dissertation","venue":"","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vanderbilt University; Hospital for Sick Children; Universidade de Macau; University of Toronto; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"MHC class I; Major histocompatibility complex; Biology; Cell biology; Transporter associated with antigen processing; Blastocyst; MHC restriction; Embryonic stem cell; Antigen processing; CD8; CD74; Chaperone (clinical); Embryo; Immune system; Immunology; Genetics; Embryogenesis; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005779904,0.0005585449,0.0003102495,0.0009712,0.0004247512,0.0006714013,0.0008337089,0.0009988724,0.005358559],"category_scores_gemma":[0.0002708913,0.0005710054,0.000472987,0.0005414165,0.0005114928,0.0003826425,0.0005138828,0.001474083,0.003622709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004507463,"about_ca_system_score_gemma":0.0004272464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006480187,"about_ca_topic_score_gemma":0.001209225,"domain_scores_codex":[0.999471,0.0000960477,0.00008171037,0.0001131944,0.0001860483,0.00005194828],"domain_scores_gemma":[0.9998084,0.00003263128,0.00004488101,0.00006002984,0.00002841307,0.00002573923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002412905,0.00009748821,0.0004738515,0.0003333179,0.00002465593,0.0005065821,0.0001619148,0.000177387,0.9657362,0.008510522,0.002436931,0.0213],"study_design_scores_gemma":[0.0001312724,0.0005341451,0.00586698,0.0001591135,0.00008023084,0.001464507,0.00009703157,0.001136072,0.6415366,0.001787891,0.3471749,0.00003127989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4176647,0.09908302,0.3035923,0.004536996,0.004833151,0.003697254,0.02958848,0.006916326,0.1300878],"genre_scores_gemma":[0.6474836,0.03336351,0.1787332,0.002179706,0.0004378674,0.005131815,0.02028819,0.0008233279,0.1115586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005358559,"threshold_uncertainty_score":0.0179261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792755604459662,"score_gpt":0.2571516507313358,"score_spread":0.2392240946867392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}