{"id":"W2595986426","doi":"10.1200/jco.2004.22.90140.3033","title":"A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of OGX-011, a 2'methoxyethyl phosphorothioate antisense to <i>clusterin</i>, in patients with prostate cancer prior to radical prostatectomy","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; BC Cancer Agency","funders":"","keywords":"Clusterin; Medicine; Prostate cancer; Flutamide; Prostate; Urology; Prostatectomy; Pharmacokinetics; Pharmacodynamics; LNCaP; Internal medicine; Peripheral blood mononuclear cell; Oncology; Cancer; Endocrinology; Androgen receptor; Apoptosis; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00090168,0.001514513,0.001513799,0.0003567281,0.0004357539,0.0009299061,0.000634865,0.0009271977,0.002046376],"category_scores_gemma":[0.0006901464,0.000687326,0.0009338169,0.0003500624,0.001139731,0.0007124718,0.0002733023,0.003090503,0.0005036972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009818573,"about_ca_system_score_gemma":0.00156881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009569543,"about_ca_topic_score_gemma":0.001922917,"domain_scores_codex":[0.9996691,0.0001286301,0.00001237284,0.00006919527,0.00003152788,0.00008913891],"domain_scores_gemma":[0.9993636,0.00009627167,0.0001322856,0.00006049457,0.00002632644,0.000321021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.614612,0.1361213,0.01466893,0.0005032655,0.0007804417,0.0003811153,0.0007502295,0.005640614,0.1406875,0.0003407378,0.003085961,0.08242789],"study_design_scores_gemma":[0.1942004,0.7754728,0.01848271,0.00001648861,0.0002279019,0.0003094374,0.00006953407,0.001254995,0.007882226,0.0001374792,0.00190887,0.00003718311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973885,0.0003640763,0.0002928987,0.0001200399,0.00002872084,0.0008391522,0.0002893322,0.00004544897,0.0006316518],"genre_scores_gemma":[0.9952251,0.0004417537,0.0007583972,0.0003193695,0.00006652858,0.001013728,0.0008191944,0.00002073921,0.001335147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046376,"threshold_uncertainty_score":0.007123888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688705222068034,"score_gpt":0.4775213126929641,"score_spread":0.4306342604722838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}