{"id":"W2595987262","doi":"10.1136/jmedgenet-2016-104247","title":"Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus","year":2017,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Heart, Lung, and Blood Institute; Versus Arthritis; Arthritis Research UK; Wellcome Trust; Wellcome","keywords":"Locus (genetics); Single-nucleotide polymorphism; Biology; Genetics; Allele; Gene; Genome-wide association study; Genotype; Genetic association; Case-control study; Computational biology; Immunology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.005654192,0.0003128249,0.001108934,0.0001554876,0.0004631073,0.0001345928,0.001428801,0.0003880781,0.0004163296],"category_scores_gemma":[0.01518186,0.0001635434,0.0002909443,0.0001997661,0.000559352,0.00006307771,0.0004942254,0.0009615012,0.00008790987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006428431,"about_ca_system_score_gemma":0.0009256219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002314243,"about_ca_topic_score_gemma":0.0004980408,"domain_scores_codex":[0.9922584,0.0004442717,0.001238312,0.0003627868,0.005019961,0.0006763003],"domain_scores_gemma":[0.993161,0.001180138,0.001491511,0.001493906,0.001353633,0.001319856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.001253917,0.0004817095,0.9652659,0.0005720296,0.0006838033,0.001824679,0.001281844,0.00006914559,0.006346421,0.000005901742,0.01974074,0.00247387],"study_design_scores_gemma":[0.05512856,0.008819884,0.2977701,0.04770343,0.001973801,0.5347616,0.01676276,0.005583482,0.02033893,0.0003476459,0.009136367,0.001673497],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858692,0.0027878,0.000535099,0.008779161,0.0008044521,0.0009137909,0.00001602314,0.00002385994,0.0002706601],"genre_scores_gemma":[0.9959421,0.0004171524,0.0001732436,0.0003528455,0.0006866106,0.00001738516,0.000002589775,0.00006193798,0.002346122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6674959,"threshold_uncertainty_score":0.9931137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04043131758813853,"score_gpt":0.33256924638491,"score_spread":0.2921379287967715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}