{"id":"W2596049017","doi":"10.1002/pro.3138","title":"Structural and dynamic characterization of a freestanding acyl carrier protein involved in the biosynthesis of cyclic lipopeptide antibiotics","year":2017,"lang":"en","type":"article","venue":"Protein Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Nonribosomal peptide; Acyl carrier protein; Stereochemistry; Polyketide synthase; Lipopeptide; Biosynthesis; Acylation; Biochemistry; Chemistry; Peptide; Moiety; Polyketide; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000951227,0.0001123331,0.0002455866,0.0001511099,0.000252689,0.00007778267,0.0004405352,0.00005443353,0.000008727235],"category_scores_gemma":[0.001477429,0.00006657338,0.00003145862,0.0003100757,0.001100443,0.0003311061,0.0001294149,0.0001240696,3.521022e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003379454,"about_ca_system_score_gemma":0.0001059789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002111585,"about_ca_topic_score_gemma":0.00007065303,"domain_scores_codex":[0.9988525,0.00004221816,0.0002777776,0.0002879371,0.0003351897,0.0002043613],"domain_scores_gemma":[0.998917,0.00002029138,0.0003488777,0.0005347174,0.0001333167,0.00004584266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004760158,0.000017072,0.009598191,0.0001569665,0.0000037738,0.000002282713,0.0003406975,7.39026e-8,0.9834148,0.0001399922,2.332097e-7,0.006278296],"study_design_scores_gemma":[0.0001683625,0.00006893034,0.2261293,0.0004486479,0.00001154446,0.00000480199,0.00008687711,0.0002985279,0.772633,0.00007624119,0.00000898304,0.0000647924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972376,0.00005023267,0.000009265467,0.001463441,0.00003427283,0.001125018,0.0000265837,0.000006346229,0.00004720167],"genre_scores_gemma":[0.9989003,0.00001949423,0.0009814658,0.00002293503,0.00002450892,9.459182e-7,0.00000199132,0.000006437921,0.0000419376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165311,"threshold_uncertainty_score":0.4054629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061527275522368,"score_gpt":0.2757909001347906,"score_spread":0.2551756273795669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}