{"id":"W2596049017","doi":"10.1002/pro.3138","title":"Structural and dynamic characterization of a freestanding acyl carrier protein involved in the biosynthesis of cyclic lipopeptide antibiotics","year":2017,"lang":"en","type":"article","venue":"Protein Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Nonribosomal peptide; Acyl carrier protein; Stereochemistry; Polyketide synthase; Lipopeptide; Biosynthesis; Acylation; Biochemistry; Chemistry; Peptide; Moiety; Polyketide; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006857932,0.0001736908,0.000141686,0.0001350409,0.0001282208,0.0001576912,0.0001649169,0.0001898609,0.0004470547],"category_scores_gemma":[0.0001605065,0.00006577181,0.0001552166,0.000162109,0.0001723154,0.0001309753,0.0001142077,0.000196215,0.0001224531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003156231,"about_ca_system_score_gemma":0.00008581698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006604128,"about_ca_topic_score_gemma":0.0003109204,"domain_scores_codex":[0.9999681,0.000004628798,0.000002700405,0.00001055174,0.000008436259,0.000005598502],"domain_scores_gemma":[0.9998816,0.00002110861,0.00003079644,0.000009582302,0.00001834812,0.00003852453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008065084,0.00001836729,0.0006390843,0.00002577021,0.000005502881,0.00009250289,0.00002075912,0.0001478928,0.9984224,0.00004858673,0.00002037487,0.0004780843],"study_design_scores_gemma":[0.00004437262,0.0003891874,0.04107535,0.00001714241,0.00004500353,0.0008463199,0.0001789655,0.01894076,0.9344045,0.0001966941,0.00383776,0.00002395251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985305,0.0002412698,0.0008088679,0.00003781246,0.00000750651,0.000006038373,0.0001667071,0.00001033501,0.0001909774],"genre_scores_gemma":[0.9973814,0.0001249407,0.001281348,0.0000233473,0.000007229244,0.000009703484,0.0007566695,0.000008696315,0.0004066712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006604128,"threshold_uncertainty_score":0.00229001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061527275522368,"score_gpt":0.2757909001347906,"score_spread":0.2551756273795669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}