{"id":"W2596100802","doi":"10.1242/jcs.202200","title":"Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay","year":2017,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundação para a Ciência e a Tecnologia; Medical Center, University of Rochester; University of Toronto","keywords":"Biology; Spliceosome; Protein subunit; Exon; Nonsense-mediated decay; Nonsense; Genetics; Cell biology; RNA splicing; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001593925,0.0002327272,0.0002783344,0.0001009414,0.00009561975,0.0002038986,0.0001740225,0.0002494579,0.001126642],"category_scores_gemma":[0.0001017678,0.0001116664,0.0002228424,0.0001133519,0.0001958238,0.0001119546,0.0001305019,0.0005142405,0.0003172041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000201743,"about_ca_system_score_gemma":0.0001642209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004984461,"about_ca_topic_score_gemma":0.00074465,"domain_scores_codex":[0.9998807,0.00002024463,0.00001485381,0.00002063384,0.00002878275,0.00003483858],"domain_scores_gemma":[0.9999224,0.0000223752,0.00002032066,0.00001134517,0.000005221305,0.00001836307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402572,0.00002264701,0.00005482816,0.00002224473,0.000003971432,0.00002325768,0.000004092812,0.00001987137,0.9991025,0.00005783595,0.00003157365,0.0005169299],"study_design_scores_gemma":[0.00003965875,0.0002378252,0.002383877,0.000003473644,0.000009739449,0.0001024552,0.000009828022,0.0008390895,0.9951724,0.00004226321,0.001157052,0.000002404426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938179,0.001596785,0.002319931,0.0001129133,0.00004649586,0.00002412083,0.0004813285,0.0001125413,0.001488022],"genre_scores_gemma":[0.9961737,0.0008971467,0.001182695,0.00005447873,0.00001046552,0.00002850331,0.0005044334,0.00001757678,0.001130966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126642,"threshold_uncertainty_score":0.003768981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337460632220031,"score_gpt":0.3160030123213713,"score_spread":0.2822569490993682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}