{"id":"W2596175104","doi":"10.1182/blood.v126.23.87.87","title":"Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Missense mutation; Mutation; Cog; Biology; Myeloid leukemia; Exome sequencing; Exome; Point mutation; Genetics; Cancer research; Fms-Like Tyrosine Kinase 3; Leukemia; Gene; Oncology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00148087,0.0004253089,0.0004112318,0.0005180851,0.0004149584,0.0006720863,0.000528067,0.0004975356,0.0008787233],"category_scores_gemma":[0.001654757,0.0001411955,0.000322813,0.0009067752,0.0004603346,0.0001887949,0.0007567057,0.0004577171,0.0002870067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009520239,"about_ca_system_score_gemma":0.001118683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005906702,"about_ca_topic_score_gemma":0.009581272,"domain_scores_codex":[0.9993013,0.0001151117,0.00004175913,0.0001764313,0.0002751305,0.0000901024],"domain_scores_gemma":[0.999145,0.000258352,0.0001452327,0.00008749831,0.0002275715,0.0001362484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005154978,0.0005820219,0.6517825,0.0005929324,0.0005686359,0.001996421,0.0007468386,0.004791499,0.2387644,0.00141662,0.01762998,0.07597326],"study_design_scores_gemma":[0.000925264,0.001944407,0.8423184,0.0001011409,0.0008777365,0.006297695,0.0005370157,0.006776516,0.08138405,0.001039443,0.05774375,0.0000547026],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803182,0.001571547,0.001141602,0.0003591058,0.00001695818,0.0001302928,0.01436249,0.000101211,0.001998613],"genre_scores_gemma":[0.949066,0.00105142,0.00689293,0.0006999432,0.00003694498,0.000179123,0.04117407,0.00006208345,0.0008373045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005906702,"threshold_uncertainty_score":0.01174462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06235173547707459,"score_gpt":0.2886760580240136,"score_spread":0.226324322546939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}