{"id":"W2596220192","doi":"10.3389/fncel.2017.00058","title":"Mitochondrial Dysfunction in the Pathogenesis of Rett Syndrome: Implications for Mitochondria-Targeted Therapies","year":2017,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Rett syndrome; MECP2; Neurodevelopmental disorder; Mitochondrion; Oxidative stress; Mitochondrial DNA; Mitochondrial disease; Neuroscience; Biology; Pathogenesis; Bioinformatics; Genetics; Gene; Endocrinology; Phenotype; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002729463,0.0003175673,0.0006213752,0.0002153891,0.000177958,0.00005875912,0.001272269,0.0002557744,7.503155e-7],"category_scores_gemma":[0.0002436441,0.0002520745,0.0003083738,0.0003302722,0.0002608445,0.00000782887,0.000124161,0.0001647722,5.214613e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002271963,"about_ca_system_score_gemma":0.0002471084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006099884,"about_ca_topic_score_gemma":0.00001494276,"domain_scores_codex":[0.9979438,0.0002064549,0.0005554215,0.0007744135,0.0001773445,0.00034261],"domain_scores_gemma":[0.9985505,0.00002962911,0.0004216638,0.0009166847,0.00004101465,0.00004046357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008994421,0.000490177,0.001353375,0.003129239,0.00005560116,0.00002181656,0.0002128649,0.0000554616,0.4604174,0.00004901476,0.008769104,0.5253561],"study_design_scores_gemma":[0.0004376191,0.0002521554,0.005714424,0.0003478416,0.00008079378,0.00002670806,0.00004638338,0.00001957046,0.0007003027,0.0001562936,0.9918349,0.000382972],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002912645,0.9859172,0.005826664,0.00008820007,0.002962207,0.00206458,0.0001806323,0.000005068423,0.0000428378],"genre_scores_gemma":[0.003865873,0.992786,0.002173981,0.00008176608,0.00004118681,0.0005652223,0.0002189291,0.00004555406,0.0002214268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9830658,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04616952789911954,"score_gpt":0.3001675231145342,"score_spread":0.2539979952154147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}