{"id":"W2596456348","doi":"10.1007/s40262-017-0526-4","title":"Population Pharmacokinetic Analysis of Ixazomib, an Oral Proteasome Inhibitor, Including Data from the Phase III TOURMALINE-MM1 Study to Inform Labelling","year":2017,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Takeda Oncology","keywords":"Ixazomib; Pharmacology; Proteasome inhibitor; Pharmacokinetics; Population; Chemistry; Medicine; Proteasome; Biochemistry; Carfilzomib","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004437456,0.0006086566,0.001292441,0.0004109982,0.000129449,0.0007181584,0.0004337323,0.0004456734,0.001274224],"category_scores_gemma":[0.003877934,0.0003452455,0.001532214,0.0006444434,0.0002296039,0.0003099662,0.000381679,0.001006466,0.0002805376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006614184,"about_ca_system_score_gemma":0.001187686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002740724,"about_ca_topic_score_gemma":0.002178596,"domain_scores_codex":[0.9985815,0.0008634714,0.00006214458,0.0002276964,0.0001954937,0.00006972977],"domain_scores_gemma":[0.9984957,0.0008009105,0.0003013712,0.0001882874,0.0001495629,0.00006406712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.07175335,0.002885455,0.3232251,0.00141743,0.01731239,0.001266473,0.0008588397,0.3788882,0.05268772,0.0020133,0.01114986,0.1365419],"study_design_scores_gemma":[0.006304905,0.03180251,0.5307066,0.00007339496,0.009585671,0.00243153,0.0001740116,0.3773959,0.01820944,0.002303208,0.02076321,0.0002495965],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804125,0.00123677,0.0113512,0.0001239324,0.00001238929,0.0003372844,0.005127947,0.000157056,0.001240988],"genre_scores_gemma":[0.9822754,0.0004040088,0.005143207,0.0001150899,0.00001698784,0.0003460601,0.01103682,0.00004349178,0.0006189767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004437456,"threshold_uncertainty_score":0.02346784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.23345354210639,"score_gpt":0.4951004790580315,"score_spread":0.2616469369516415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}