{"id":"W2596479444","doi":"10.1182/blood.v118.21.2051.2051","title":"Pharmacodynamic, Biodistribution and Toxicology Results for SNS01-T, a Nanoparticle That Targets eIF5A for the Treatment of Multiple Myeloma","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Biodistribution; Apoptosis; Small interfering RNA; Biology; Pharmacokinetics; In vivo; Cancer research; Pharmacology; Molecular biology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003840681,0.0003336428,0.0002890217,0.0002534474,0.000209193,0.0003019621,0.0001772021,0.0003984916,0.001182193],"category_scores_gemma":[0.0003781287,0.0001696259,0.0003608437,0.0002052894,0.0002648778,0.000222836,0.000103886,0.0005405928,0.0003278949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004167242,"about_ca_system_score_gemma":0.0005677003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845365,"about_ca_topic_score_gemma":0.001244114,"domain_scores_codex":[0.9998674,0.00004301401,0.000005770979,0.00002303775,0.00004270232,0.00001808752],"domain_scores_gemma":[0.9997752,0.00007289733,0.00004962006,0.00001522767,0.00005037561,0.00003661054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004224567,0.000662246,0.001123895,0.0001442528,0.00006385138,0.0001570243,0.00009890788,0.002415767,0.9724492,0.0001433258,0.0005009722,0.0180159],"study_design_scores_gemma":[0.0002590127,0.01678519,0.007156233,0.0000144225,0.000181392,0.0005750866,0.00008763251,0.009196197,0.9621329,0.00007474099,0.003512643,0.00002457847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875855,0.001815039,0.006906424,0.0001645724,0.00004638618,0.0001868953,0.0003457183,0.0001273775,0.002822045],"genre_scores_gemma":[0.9927556,0.001024232,0.003237959,0.0000768778,0.00001781081,0.00009827243,0.0003475374,0.00005405393,0.002387774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001845365,"threshold_uncertainty_score":0.003954828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02947218919193904,"score_gpt":0.270201903147026,"score_spread":0.240729713955087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}