{"id":"W2596496142","doi":"10.1182/blood.v128.22.5391.5391","title":"Comparison of Pharmacokinetics and Pharmacodynamics of Two Anti-CD20 Monoclonal Antibodies (Candidate Biosimilar DRL-Rituximab and Innovator Reference Product Rituximab (Mabthera®) in a Randomised, Multi-Centre, Double-Blind, Parallel Group Study of CHOP with Rituximab Chemotherapy in Patients with CD20-Positive Diffuse Large B-Cell Lymphoma","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Rituximab; Medicine; Pharmacodynamics; Cmax; Biosimilar; Internal medicine; Pharmacokinetics; Prednisone; Pharmacology; European union; CHOP; Cyclophosphamide; Vincristine; Gastroenterology; Oncology; Lymphoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003068032,0.000945801,0.002485924,0.0004145524,0.0003048207,0.001148926,0.0007298287,0.001519337,0.001880209],"category_scores_gemma":[0.004657798,0.0007696314,0.001490916,0.0004423456,0.00126131,0.001336737,0.0004687666,0.002024525,0.0005252613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008134151,"about_ca_system_score_gemma":0.0008558945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889016,"about_ca_topic_score_gemma":0.0003469897,"domain_scores_codex":[0.9973435,0.001700967,0.0001704039,0.0003890984,0.0002337107,0.0001622969],"domain_scores_gemma":[0.99741,0.0007697392,0.0006692701,0.0002477478,0.0001846889,0.0007186078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9541829,0.01490903,0.002378895,0.0002413211,0.0005906568,0.00004005448,0.00012531,0.000598756,0.01188269,0.00005267407,0.0001614274,0.01483622],"study_design_scores_gemma":[0.3930371,0.5924041,0.009322214,0.000015853,0.0006698805,0.00008866861,0.00004618912,0.001214498,0.002516451,0.00009309429,0.0005535936,0.00003825315],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978275,0.0007562892,0.0003319649,0.00007330671,0.00007121675,0.0005656371,0.0001004888,0.00002115324,0.0002524244],"genre_scores_gemma":[0.9975922,0.0003342543,0.0006548794,0.0001445578,0.0001314365,0.0006561445,0.0001695407,0.000008715806,0.0003083608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003068032,"threshold_uncertainty_score":0.01622546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02019780311363597,"score_gpt":0.3060211205919383,"score_spread":0.2858233174783023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}