{"id":"W2596496142","doi":"10.1182/blood.v128.22.5391.5391","title":"Comparison of Pharmacokinetics and Pharmacodynamics of Two Anti-CD20 Monoclonal Antibodies (Candidate Biosimilar DRL-Rituximab and Innovator Reference Product Rituximab (Mabthera®) in a Randomised, Multi-Centre, Double-Blind, Parallel Group Study of CHOP with Rituximab Chemotherapy in Patients with CD20-Positive Diffuse Large B-Cell Lymphoma","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Rituximab; Medicine; Pharmacodynamics; Cmax; Biosimilar; Internal medicine; Pharmacokinetics; Prednisone; Pharmacology; European union; CHOP; Cyclophosphamide; Vincristine; Gastroenterology; Oncology; Lymphoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004850301,0.0004876244,0.001578269,0.0003385526,0.0000611599,0.00001350893,0.0002600541,0.0001824064,0.00001779207],"category_scores_gemma":[0.00002094051,0.000308578,0.0000539919,0.0004874364,0.000640239,0.0001483891,0.0001453925,0.0002721612,6.288433e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002586663,"about_ca_system_score_gemma":0.00005748243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001344548,"about_ca_topic_score_gemma":0.0002362813,"domain_scores_codex":[0.9972008,0.0004056662,0.001001142,0.0007123781,0.0001643228,0.0005157219],"domain_scores_gemma":[0.9984577,0.0002017198,0.0006533798,0.0003302275,0.0003005698,0.00005644878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.06496266,0.1158928,0.7351511,0.0001795666,0.0007322068,0.000008624788,0.001081905,9.268086e-7,0.08030006,0.00002662572,0.000005009434,0.001658571],"study_design_scores_gemma":[0.6873783,0.00151618,0.1650105,0.0002516401,0.0003806781,0.000005090548,0.0002196075,0.00008491644,0.1447786,0.00000513978,0.00002066729,0.0003486175],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956393,0.00167236,0.0001482693,0.0000779967,0.00004587407,0.002020972,0.0003654514,0.00001622735,0.00001349877],"genre_scores_gemma":[0.9965032,0.0007512642,0.002555698,0.0000482592,0.000008951816,0.00003373689,0.00004455484,0.00003860789,0.00001566715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6224157,"threshold_uncertainty_score":0.9999366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02019780311363597,"score_gpt":0.3060211205919383,"score_spread":0.2858233174783023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}