{"id":"W2596506481","doi":"10.1093/infdis/jix024","title":"Pegylated Interferon Alfa-2b Add-on Treatment in Hepatitis B Virus Envelope Antigen-Positive Chronic Hepatitis B Patients Treated with Nucleos(t)ide Analogue: A Randomized, Controlled Trial (PEGON)","year":2017,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Gilead Sciences; Abbott Laboratories","keywords":"Medicine; HBeAg; Internal medicine; Gastroenterology; Seroconversion; Peginterferon alfa-2a; Entecavir; Combination therapy; Pegylated interferon; Hepatitis B virus; Randomized controlled trial; Adverse effect; Hepatitis B; Immunology; Lamivudine; HBsAg; Chronic hepatitis; Virus; Ribavirin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001963449,0.001257956,0.002343393,0.0003792057,0.0003562343,0.0008229645,0.0007089991,0.001679292,0.005216947],"category_scores_gemma":[0.002156169,0.0005362988,0.001514409,0.000373539,0.0009979355,0.0006743923,0.0003613197,0.001838294,0.000505886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005078691,"about_ca_system_score_gemma":0.0009886279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008220287,"about_ca_topic_score_gemma":0.001532743,"domain_scores_codex":[0.9990944,0.0005854032,0.00007118339,0.0001083088,0.00005322057,0.00008749762],"domain_scores_gemma":[0.9989403,0.0003695296,0.0002562914,0.00007131658,0.00006887539,0.0002938182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9839203,0.003651201,0.0005182195,0.0005463898,0.000496462,0.00002378876,0.00002779382,0.0001192618,0.001209298,0.00003828399,0.0002387484,0.009210173],"study_design_scores_gemma":[0.9744514,0.02413973,0.0006784023,0.00002512793,0.0002434257,0.00001328549,0.000006730596,0.0001149079,0.0001358679,0.00002749706,0.0001598398,0.000003604251],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990035,0.003946471,0.0003476219,0.0005506105,0.0005294508,0.002968049,0.0004559986,0.00006481596,0.001101926],"genre_scores_gemma":[0.9865944,0.003751381,0.001361072,0.0009466054,0.0007676408,0.004363565,0.0005961458,0.00001517339,0.001604027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005216947,"threshold_uncertainty_score":0.01745248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009156460522759861,"score_gpt":0.2626140961784473,"score_spread":0.2534576356556874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}