{"id":"W2596512443","doi":"10.3390/molecules22030461","title":"Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Helwan University","keywords":"In vivo; Pyrrole; Chemistry; In vitro; Biological activity; Docking (animal); Combinatorial chemistry; Molecule; Stereochemistry; Proton NMR; Nuclear magnetic resonance spectroscopy; Anti-inflammatory; Biochemistry; Pharmacology; Organic chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132094,0.0003417908,0.000253657,0.0001918315,0.0001039964,0.000158687,0.0002744152,0.0002990869,0.002083873],"category_scores_gemma":[0.0001437412,0.0001014458,0.0002032063,0.0001990681,0.0001233471,0.0003135414,0.0001392599,0.0003853302,0.0003495119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863476,"about_ca_system_score_gemma":0.0001509265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002309577,"about_ca_topic_score_gemma":0.0004579249,"domain_scores_codex":[0.9999259,0.00001207374,0.000005565942,0.00001787387,0.0000207608,0.00001784946],"domain_scores_gemma":[0.999931,0.000009732456,0.00002589524,0.00000733192,0.00001071914,0.00001530253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00027579,0.00009255666,0.00009873203,0.0003566076,0.00001222611,0.0002800698,0.00003639312,0.000983801,0.9842989,0.0008103283,0.0002156389,0.01253904],"study_design_scores_gemma":[0.0001458905,0.005581492,0.003486607,0.00005869198,0.00006089078,0.001921323,0.00003658622,0.002456238,0.9573373,0.0003372577,0.02853045,0.00004725316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506958,0.02565607,0.01155156,0.0002518426,0.0001739866,0.000181826,0.001354675,0.0001741823,0.009960089],"genre_scores_gemma":[0.9753259,0.006855324,0.01322628,0.0001225038,0.00004751508,0.00008304681,0.0007457901,0.00001693484,0.003576732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002083873,"threshold_uncertainty_score":0.00697124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106767709028405,"score_gpt":0.2130201305479115,"score_spread":0.2019524534576274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}