{"id":"W2596512443","doi":"10.3390/molecules22030461","title":"Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Helwan University","keywords":"In vivo; Pyrrole; Chemistry; In vitro; Biological activity; Docking (animal); Combinatorial chemistry; Molecule; Stereochemistry; Proton NMR; Nuclear magnetic resonance spectroscopy; Anti-inflammatory; Biochemistry; Pharmacology; Organic chemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147825,0.0002005709,0.0002489278,0.00002131048,0.0003996161,0.0001520267,0.0002760848,0.0001511636,0.00006518405],"category_scores_gemma":[0.0001214974,0.0001355951,0.00005319128,0.0000180542,0.000426473,0.0001360601,0.0001592926,0.0001664716,0.00001170548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002387742,"about_ca_system_score_gemma":0.00002495289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005599781,"about_ca_topic_score_gemma":0.00009096356,"domain_scores_codex":[0.9990927,0.00002445797,0.0001202923,0.000340409,0.000173787,0.0002483362],"domain_scores_gemma":[0.9990602,0.00009923855,0.0001759476,0.0005051821,0.00002945858,0.0001299478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001187709,0.0001510697,0.2086664,0.00005074391,0.00006667493,0.00004855284,0.0000473131,0.000001252567,0.7663183,0.0001110447,0.0001089896,0.02431088],"study_design_scores_gemma":[0.0007604887,0.00004604337,0.2385615,0.00005670455,0.00002751832,0.000006532612,0.0001013703,0.0002099701,0.7525879,0.0001916352,0.007068976,0.0003813344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758686,0.00009414277,0.00002425006,0.0003268602,0.00002829171,0.00004348387,0.00002645911,0.00008834451,0.02349954],"genre_scores_gemma":[0.9994704,0.0000423261,0.0001591705,0.000084785,0.00009565368,0.00001592599,0.000008421153,0.00001752365,0.0001057602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02989511,"threshold_uncertainty_score":0.5529406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106767709028405,"score_gpt":0.2130201305479115,"score_spread":0.2019524534576274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}