{"id":"W2596636194","doi":"10.1182/blood.v128.22.1812.1812","title":"A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Phagocytosis; Immune system; Cancer research; Immunology; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002931452,0.0002124123,0.0005007789,0.0001517324,0.00008036436,0.000005896088,0.000165453,0.0001680152,0.0001104413],"category_scores_gemma":[0.0002068879,0.0001170759,0.00006167829,0.0002043263,0.0001155165,0.0001788822,0.00009373617,0.0001384185,0.0000202209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003836119,"about_ca_system_score_gemma":0.00006195755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005039206,"about_ca_topic_score_gemma":0.00001718697,"domain_scores_codex":[0.9984514,0.0001458716,0.0006973533,0.0003181166,0.00007131696,0.0003159829],"domain_scores_gemma":[0.9989814,0.0001132116,0.0004394257,0.0003281319,0.0001222286,0.00001558203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001677625,0.02051915,0.05078685,0.00002744755,0.0001814067,0.000005760198,0.0008370776,3.949795e-7,0.9253435,0.00001489957,0.00002044445,0.0005854897],"study_design_scores_gemma":[0.08084562,0.007779107,0.2254837,0.0003947979,0.0001087498,0.00001510898,0.0008166007,4.962977e-7,0.6840494,0.000007745271,0.0002226788,0.0002760176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983396,0.0007328817,0.00003124875,0.0000252977,0.0001413735,0.0006325509,0.00002478493,0.00003955371,0.00003273024],"genre_scores_gemma":[0.9995375,0.00001337948,0.000105991,0.00000799075,0.00001035214,0.00005774068,0.0000347218,0.00002098256,0.0002113767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2412941,"threshold_uncertainty_score":0.4774215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393267562949513,"score_gpt":0.2340409575748627,"score_spread":0.2201082819453676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}