{"id":"W2596636194","doi":"10.1182/blood.v128.22.1812.1812","title":"A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Phagocytosis; Immune system; Cancer research; Immunology; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082102,0.001444027,0.001894936,0.0004643126,0.0004332431,0.001066142,0.0007077664,0.001126235,0.003077775],"category_scores_gemma":[0.0004984565,0.000481197,0.001079835,0.0003340451,0.0006495193,0.0007186788,0.0003203621,0.00198961,0.0007808793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013534,"about_ca_system_score_gemma":0.001387851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137503,"about_ca_topic_score_gemma":0.002469672,"domain_scores_codex":[0.999707,0.0001024854,0.00001261433,0.00006895994,0.00002886386,0.00008000149],"domain_scores_gemma":[0.9996625,0.00003759445,0.00004821454,0.00002485117,0.00002499866,0.0002016973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4554346,0.1384482,0.0220428,0.001689008,0.002179855,0.001236893,0.0006750804,0.006098271,0.1590893,0.00085955,0.009528561,0.202718],"study_design_scores_gemma":[0.2562356,0.7108914,0.01652327,0.0000512494,0.0005434085,0.0006954225,0.0001049655,0.001682883,0.007925839,0.0003027871,0.005004109,0.00003906624],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905326,0.002504768,0.0007044673,0.0004569497,0.0001180601,0.002703299,0.00122701,0.00009988393,0.001652911],"genre_scores_gemma":[0.9881045,0.001907212,0.001286791,0.000891358,0.0001650215,0.002316162,0.002074273,0.00002920302,0.003225478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003077775,"threshold_uncertainty_score":0.01029617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393267562949513,"score_gpt":0.2340409575748627,"score_spread":0.2201082819453676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}