{"id":"W2596837612","doi":"10.1182/blood.v128.22.221.221","title":"Analysis of a Global Registration Trial of the Efficacy and Safety of CTL019 in Pediatric and Young Adults with Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Clinical endpoint; Clinical trial; Internal medicine; Cytokine release syndrome; Adverse effect; Salvage therapy; Oncology; Chimeric antigen receptor; Chemotherapy; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005865202,0.001137548,0.001293385,0.0003265964,0.0003357375,0.0008753501,0.0007075816,0.001002423,0.003052923],"category_scores_gemma":[0.00292302,0.0003731821,0.001527774,0.0004384479,0.001283548,0.0007547853,0.0007199274,0.00220577,0.0005908951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007064046,"about_ca_system_score_gemma":0.001667453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005374956,"about_ca_topic_score_gemma":0.001325471,"domain_scores_codex":[0.9971872,0.002207932,0.00008504862,0.0002210319,0.0001098084,0.0001889407],"domain_scores_gemma":[0.9975173,0.0007174353,0.0005739735,0.0003165632,0.0001375614,0.0007370527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.906146,0.01675612,0.02386604,0.0004263244,0.002172404,0.0003275272,0.0002832358,0.001159261,0.01194958,0.0005116793,0.0025445,0.03385733],"study_design_scores_gemma":[0.5152022,0.4437819,0.03168755,0.0000335093,0.001544184,0.0003018978,0.0001547096,0.0009515177,0.002777101,0.0004131252,0.003119883,0.00003239073],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950193,0.0009382506,0.0004869539,0.0004475274,0.00005805555,0.001161385,0.0009410281,0.00003785516,0.0009096143],"genre_scores_gemma":[0.9943407,0.0004704427,0.0009336827,0.0005709546,0.00009498312,0.001135601,0.001720186,0.00001899396,0.0007145057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005865202,"threshold_uncertainty_score":0.0310185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009385437605929787,"score_gpt":0.2620527594645376,"score_spread":0.2526673218586078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}