{"id":"W2596854072","doi":"10.1016/j.neurobiolaging.2017.03.012","title":"Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease","year":2017,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Deutsche Parkinson Vereinigung; H. Lundbeck A/S; Britannia Pharmaceuticals; Stifterverband; NIHR Cambridge Biomedical Research Centre; Rosetrees Trust; Newcastle University; Alzheimer's Society; Wellcome Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Teva Pharmaceutical Industries; TauRx Pharmaceuticals; Medical Research Council; Biogen; GlaxoSmithKline; Parkinson's UK; ACADIA Pharmaceuticals; Eli Lilly and Company; Bristol-Myers Squibb; Michael J. Fox Foundation for Parkinson's Research","keywords":"Atrophy; Cardiology; Internal medicine; Cognitive decline; Parkinson's disease; Medicine; Surrogate endpoint; Ventricular volume; Degenerative disease; Psychology; Central nervous system disease; Cognitive impairment; Disease; Dementia; Ejection fraction; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215205,0.000158004,0.0002972536,0.0001356134,0.0001418712,0.00001644827,0.0001065185,0.00004362987,0.0000305615],"category_scores_gemma":[0.00006371309,0.0001379661,0.00007851978,0.00004292529,0.0001253265,0.00006725419,0.0001368089,0.0001052252,0.000008472531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002951111,"about_ca_system_score_gemma":0.00003814622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003772662,"about_ca_topic_score_gemma":0.000007018119,"domain_scores_codex":[0.9990008,0.00005538869,0.0001906973,0.0003877648,0.00009784709,0.0002674281],"domain_scores_gemma":[0.999226,0.00002943913,0.0001550895,0.0003937175,0.00002760474,0.000168164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001863184,0.000294196,0.9940668,0.00007496529,0.00008826052,0.001429915,0.00002144723,0.000005021614,0.00240345,0.0001154807,0.0001553486,0.001158822],"study_design_scores_gemma":[0.003262595,0.00022987,0.9854361,0.000117782,0.000144253,0.00001945169,0.00001079491,0.00009921224,0.001450254,0.0001387602,0.008996246,0.0000947224],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947866,0.0006656235,0.00004214059,0.003942136,0.0001328198,0.0002910745,0.0000292027,0.00001714784,0.00009324869],"genre_scores_gemma":[0.9991508,0.00006252365,0.0002056751,0.0003732986,0.0000407137,0.00002233461,0.00003804285,0.00001319922,0.00009337085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008840897,"threshold_uncertainty_score":0.5626096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909131274380797,"score_gpt":0.2778024691880698,"score_spread":0.2587111564442618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}