{"id":"W2596854072","doi":"10.1016/j.neurobiolaging.2017.03.012","title":"Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease","year":2017,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Deutsche Parkinson Vereinigung; H. Lundbeck A/S; Britannia Pharmaceuticals; Stifterverband; NIHR Cambridge Biomedical Research Centre; Rosetrees Trust; Newcastle University; Alzheimer's Society; Wellcome Trust; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Teva Pharmaceutical Industries; TauRx Pharmaceuticals; Medical Research Council; Biogen; GlaxoSmithKline; Parkinson's UK; ACADIA Pharmaceuticals; Eli Lilly and Company; Bristol-Myers Squibb; Michael J. Fox Foundation for Parkinson's Research","keywords":"Atrophy; Cardiology; Internal medicine; Cognitive decline; Parkinson's disease; Medicine; Surrogate endpoint; Ventricular volume; Degenerative disease; Psychology; Central nervous system disease; Cognitive impairment; Disease; Dementia; Ejection fraction; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004925909,0.0002145438,0.0002812419,0.0003569557,0.0002184336,0.0002305562,0.0001351044,0.0002361138,0.0003583526],"category_scores_gemma":[0.000927484,0.0001292286,0.00016852,0.0001918905,0.0001896174,0.000287554,0.0002433275,0.0002272322,0.00007447969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321664,"about_ca_system_score_gemma":0.00009185443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222568,"about_ca_topic_score_gemma":0.002593046,"domain_scores_codex":[0.999891,0.00003056698,0.00001236135,0.00003244712,0.00002135953,0.00001225811],"domain_scores_gemma":[0.9996196,0.00007460204,0.0001486643,0.00002929242,0.00005994071,0.0000678529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002601587,0.0002229943,0.9599853,0.00006656215,0.0001881261,0.0007346555,0.0004219361,0.0002416488,0.01532968,0.00002514259,0.0001204318,0.02006193],"study_design_scores_gemma":[0.00001093445,0.0004577914,0.9985263,0.00000325138,0.00002235675,0.0003732859,0.00003066242,0.00007789311,0.000365262,0.00002080995,0.0001091868,0.000002197714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992191,0.0005279066,0.00006276767,0.000005948038,0.000001409214,0.000003747809,0.00005449928,0.000002429757,0.0001221602],"genre_scores_gemma":[0.9994028,0.0001774807,0.000112782,0.000009447973,0.000003011204,0.000006036982,0.0001517658,7.938373e-7,0.0001359912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222568,"threshold_uncertainty_score":0.002605081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909131274380797,"score_gpt":0.2778024691880698,"score_spread":0.2587111564442618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}