{"id":"W2597132924","doi":"10.15252/emmm.201607296","title":"Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti‐tumor immunity with superior safety in bladder cancer models","year":2017,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Northern Alberta Institute of Technology; Alberta Cancer Foundation; University of Alberta","funders":"University of Alberta; Alberta Cancer Foundation; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Li Ka Shing Foundation","keywords":"Vaccinia; Oncolytic virus; Ribonucleotide reductase; Virus; Virology; Immunity; Cancer research; Biology; Medicine; Immune system; Immunology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080369,0.0003717034,0.0002702394,0.0002829482,0.0001367192,0.0003005685,0.0003001764,0.0004421595,0.0008411542],"category_scores_gemma":[0.0001412091,0.0001892646,0.0003321315,0.0001281607,0.000356423,0.0002272326,0.0002000598,0.0005522114,0.0004844079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004493941,"about_ca_system_score_gemma":0.0003207126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006331468,"about_ca_topic_score_gemma":0.0006358526,"domain_scores_codex":[0.9997932,0.00004713203,0.0000218046,0.0000379007,0.00004852504,0.00005145198],"domain_scores_gemma":[0.9998659,0.00001948113,0.00005322186,0.00002246665,0.00001039864,0.0000285015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006726259,0.00001474838,0.00006296353,0.00001061419,0.000003223703,0.0000137778,0.000004700921,0.00004157494,0.9990408,0.0000975161,0.00002617958,0.0006165612],"study_design_scores_gemma":[0.00001089146,0.0001570125,0.000369314,0.000002099749,0.000009174923,0.00009360348,0.000003887827,0.0003936373,0.9976231,0.00002010902,0.001314628,0.00000244749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862605,0.001024371,0.01053409,0.000147172,0.00005329423,0.00005461252,0.0005780267,0.000277621,0.001070385],"genre_scores_gemma":[0.9894912,0.000391342,0.006455163,0.00003401918,0.000009914846,0.00002984303,0.0009245593,0.00006795065,0.002596032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008411542,"threshold_uncertainty_score":0.003260553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580922355641801,"score_gpt":0.3084292240488598,"score_spread":0.2926200004924418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}