{"id":"W2597143300","doi":"10.1097/mib.0000000000001062","title":"CYP3A4 Activity is Markedly Lower in Patients with Crohnʼs Disease","year":2017,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Crohn's disease; Medicine; Crohn disease; Gastroenterology; CYP3A4; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002842523,0.000272646,0.0005048335,0.0006463456,0.0004021113,0.0005347604,0.0001278851,0.000406651,0.002886575],"category_scores_gemma":[0.00169181,0.0001315258,0.0002743113,0.0007970644,0.000228852,0.0002158333,0.0001941596,0.0005254245,0.0003793408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002561466,"about_ca_system_score_gemma":0.0001368146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001203206,"about_ca_topic_score_gemma":0.001136789,"domain_scores_codex":[0.9996765,0.00006802042,0.00004681743,0.00009770199,0.00006488394,0.00004621043],"domain_scores_gemma":[0.9989551,0.0002744522,0.0005010447,0.00005115834,0.00009491872,0.0001233338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004107468,0.00002536173,0.9925061,0.00002786105,0.00004973552,0.0004724061,0.00005519614,0.00003315534,0.002103699,0.00001875772,0.0001440886,0.004152805],"study_design_scores_gemma":[0.00001003681,0.0001191611,0.9972361,0.000005911061,0.00004757144,0.001624982,0.00006561961,0.00009481495,0.0003012957,0.0000297087,0.000462383,0.000002396149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968351,0.001469401,0.0001889302,0.00009909572,0.00001505168,0.000005440056,0.0002417634,0.00001590743,0.00112935],"genre_scores_gemma":[0.9992588,0.0002062757,0.0001359592,0.00003676285,0.00001857611,0.00000345152,0.0001803741,0.000003618183,0.0001559961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002886575,"threshold_uncertainty_score":0.009656489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03575969491971041,"score_gpt":0.359573352400418,"score_spread":0.3238136574807076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}