{"id":"W2597159142","doi":"10.1371/journal.pone.0174101","title":"The effects of substance P and acetylcholine on human tenocyte proliferation converge mechanistically via TGF-β1","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tendon Structure and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; Vancouver Coastal Health","funders":"Svenska Läkaresällskapet; Umeå Universitet; Vetenskapsrådet; Erik och Anne Marie Detlofs Stiftelse; Västerbotten Läns Landsting","keywords":"Downregulation and upregulation; Transforming growth factor; Muscarinic acetylcholine receptor; Cell biology; Signal transduction; Receptor; Acetylcholine; Chemistry; Cell growth; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567256,0.0003131441,0.0002162111,0.0002134153,0.0001237574,0.0002623131,0.00006771825,0.0001495616,0.001129342],"category_scores_gemma":[0.0001551801,0.0001111524,0.000291159,0.0001080955,0.0002060722,0.000169987,0.0002047807,0.0004316064,0.0001756652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304665,"about_ca_system_score_gemma":0.0002326644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005037469,"about_ca_topic_score_gemma":0.0007299467,"domain_scores_codex":[0.999836,0.00005170781,0.00001474768,0.00001647466,0.0000442239,0.00003676899],"domain_scores_gemma":[0.999899,0.00003291711,0.00002520701,0.000009398624,0.00001398565,0.00001954367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003555748,0.00004826079,0.000387442,0.0000992326,0.000007857034,0.0001429218,0.00004517742,0.0000368604,0.9950697,0.00005774981,0.00001966154,0.003729512],"study_design_scores_gemma":[0.00006808998,0.002302415,0.0299677,0.00003333138,0.00005924534,0.0005306726,0.0002112646,0.0005590781,0.9629483,0.0001249111,0.003187382,0.000007749633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868772,0.008185364,0.001561334,0.0001271817,0.00004638289,0.00004653726,0.0001057953,0.00003053327,0.003019766],"genre_scores_gemma":[0.9930893,0.003834351,0.001192739,0.00009155118,0.00002141163,0.00004821934,0.0001075958,0.000003634013,0.001611203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129342,"threshold_uncertainty_score":0.003777981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03740982088531413,"score_gpt":0.2825715777729484,"score_spread":0.2451617568876343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}