{"id":"W2597309066","doi":"10.1182/blood.v128.22.243.243","title":"Higher c-MYC Expression Is Associated with Ixazomib-Lenalidomide-Dexamethasone (IRd) Progression-Free Survival (PFS) Benefit Versus Placebo-Rd: Biomarker Analysis of the Phase 3 Tourmaline-MM1 Study in Relapsed/Refractory Multiple Myeloma (RRMM)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Medicine; Lenalidomide; Internal medicine; Ixazomib; Placebo; Oncology; Progression-free survival; Clinical endpoint; Interim analysis; Proteasome inhibitor; Dexamethasone; Multiple myeloma; Randomized controlled trial; Carfilzomib; Pathology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001189153,0.0004257898,0.001007368,0.0003098743,0.0001815109,0.0006155602,0.0003340696,0.0003717051,0.002121309],"category_scores_gemma":[0.0008486859,0.0002333585,0.001274505,0.0003825164,0.0003968876,0.0002652733,0.000241433,0.0007497414,0.0001725329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000670555,"about_ca_system_score_gemma":0.0004472063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005792172,"about_ca_topic_score_gemma":0.001053529,"domain_scores_codex":[0.9994743,0.0002474942,0.0000375383,0.0001178976,0.0000611576,0.00006166914],"domain_scores_gemma":[0.9993893,0.000148603,0.0002759136,0.00003809512,0.00002203639,0.0001260805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7998124,0.003027689,0.1150917,0.0008218393,0.005286507,0.0001290083,0.00008519286,0.001346985,0.03783254,0.0001377696,0.0007398448,0.03568849],"study_design_scores_gemma":[0.1266778,0.196829,0.6380482,0.0001144062,0.01197817,0.0006781919,0.0001408991,0.0043356,0.01680205,0.0006134399,0.003714546,0.00006764397],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99672,0.002220409,0.0001251978,0.00007735533,0.00001596113,0.0001164213,0.0004894239,0.00001028004,0.0002248991],"genre_scores_gemma":[0.9988175,0.0002798521,0.0001807711,0.00006816098,0.00002376513,0.00007754377,0.0003522717,0.000001989477,0.0001980548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121309,"threshold_uncertainty_score":0.007096469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04594296410992498,"score_gpt":0.3352373117727274,"score_spread":0.2892943476628024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}