{"id":"W2597419566","doi":"10.1021/acschemneuro.6b00444","title":"Studies To Examine Potential Tolerability Differences between the 5-HT<sub>2C</sub>Receptor Selective Agonists Lorcaserin and CP-809101","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Centre for Addiction and Mental Health; Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Texas Health Science Center at San Antonio","keywords":"Tolerability; Agonist; Nausea; Pharmacology; Receptor; Pharmacokinetics; Intrinsic activity; Internal medicine; Medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007909008,0.0004120136,0.0007404851,0.0001809185,0.0001573594,0.0003301178,0.0002252724,0.0003945247,0.002748172],"category_scores_gemma":[0.001040548,0.0002071895,0.0005456863,0.0002071376,0.0003252494,0.0005617113,0.0001530277,0.0009493795,0.0003047376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563337,"about_ca_system_score_gemma":0.0002576925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003868713,"about_ca_topic_score_gemma":0.0008131778,"domain_scores_codex":[0.9996171,0.0001307928,0.00005385354,0.00005383033,0.00008481066,0.00005950559],"domain_scores_gemma":[0.9991129,0.0003141838,0.00024753,0.00008532019,0.0001231147,0.0001169037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01860955,0.003737518,0.00196065,0.0003905078,0.0001864115,0.0002808742,0.0001682193,0.0004408643,0.9561461,0.0001588385,0.0002108447,0.01770968],"study_design_scores_gemma":[0.001682379,0.441433,0.05411275,0.00002832151,0.0007039822,0.001207845,0.0003158705,0.001870716,0.4941429,0.0001714455,0.00428491,0.00004593726],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970126,0.0005162716,0.001119383,0.00005343783,0.00002454494,0.000334963,0.0003437355,0.00001940469,0.0005755929],"genre_scores_gemma":[0.9942578,0.0009724397,0.001833704,0.0002102698,0.00009585402,0.0004793565,0.0007502194,0.00002242506,0.001377804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002748172,"threshold_uncertainty_score":0.00919354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05713386771960535,"score_gpt":0.3211762067780672,"score_spread":0.2640423390584619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}