{"id":"W2597428467","doi":"10.1038/nature21725","title":"Complex pectin metabolism by gut bacteria reveals novel catalytic functions","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":631,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lethbridge College","funders":"Basic Energy Sciences; Biotechnology and Biological Sciences Research Council; Agence Nationale de la Recherche; European Commission; U.S. Department of Energy; Diamond Light Source; Wellcome Trust","keywords":"Bacteroides thetaiotaomicron; Glycan; Bacteria; Glycosyltransferase; Biochemistry; Glycoside hydrolase; Enzyme; Glycobiology; Glycosidic bond; Microbiome; Bacteroides; Microbial metabolism; Polysaccharide; Metabolism; Pectin; Biology; Chemistry; Microbiology; Glycoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001301798,0.0001336512,0.0001761905,0.000005996282,0.0006707498,0.0002335826,0.0004804977,0.0005099053,0.0009332351],"category_scores_gemma":[0.00008873537,0.00004932454,0.00008803212,0.00006072162,0.00004114661,0.0001590344,0.00008725942,0.0006656375,0.0001435966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001054475,"about_ca_system_score_gemma":0.000004565019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007557874,"about_ca_topic_score_gemma":0.0005044263,"domain_scores_codex":[0.9992031,0.00001450793,0.0001224915,0.0002573417,0.0001509455,0.0002515496],"domain_scores_gemma":[0.9995029,0.00007469959,0.0001317149,0.0001406546,0.00004512217,0.0001049065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000009373389,0.00003141531,0.0007039856,0.000002041933,0.000012499,0.000001415793,0.000008135082,7.493843e-8,0.9034483,0.0001831988,0.09105702,0.004542576],"study_design_scores_gemma":[0.0000883248,0.0000158909,0.5106584,0.000006924683,0.00001764988,0.00001185685,0.00001635577,0.00001047543,0.001741601,0.0001023396,0.4871989,0.0001312213],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862496,0.0005583963,0.00000174287,0.004084932,0.0007636555,0.0001377183,0.001770264,0.00005959125,0.006374102],"genre_scores_gemma":[0.9884393,0.00003942868,0.00005882402,0.0009032874,0.0005478244,0.000004621532,0.0005116583,9.855377e-7,0.009494045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9017066,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02548491159398728,"score_gpt":0.2444201579019105,"score_spread":0.2189352463079232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}