{"id":"W2597563837","doi":"10.1261/rna.060137.116","title":"A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery","year":2017,"lang":"en","type":"article","venue":"RNA","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; National Institutes of Health; Canada Research Chairs","keywords":"Biology; Nuclear export signal; EIF4E; Messenger RNA; Computational biology; Biotechnology; Cell biology; Biochemistry; RNA; Gene; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007359774,0.001684263,0.001111657,0.00102363,0.001348514,0.002387523,0.002025539,0.002323371,0.002342211],"category_scores_gemma":[0.0003745049,0.0006293107,0.001107728,0.0004291666,0.002537805,0.003376642,0.001448784,0.00243203,0.001738895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00220041,"about_ca_system_score_gemma":0.001638259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001257243,"about_ca_topic_score_gemma":0.001272205,"domain_scores_codex":[0.9995891,0.00005353093,0.00004637495,0.0001199722,0.00008567608,0.000105304],"domain_scores_gemma":[0.9998094,0.00002527822,0.00003793502,0.00002523997,0.00003844446,0.00006367234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002817357,0.000239358,0.0005911401,0.001356628,0.00004642348,0.004380307,0.0004828515,0.00465404,0.2925429,0.6723819,0.00266306,0.02037969],"study_design_scores_gemma":[0.0002520593,0.001185693,0.006692193,0.0006368977,0.00008864397,0.008008067,0.001291626,0.04468486,0.2183972,0.4664644,0.2519508,0.0003475079],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1977235,0.107188,0.5540146,0.02970415,0.005028116,0.001015813,0.001032017,0.003351061,0.1009428],"genre_scores_gemma":[0.7159483,0.04653973,0.2052276,0.002878105,0.001651577,0.001005186,0.001665315,0.0002411658,0.0248431],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002387523,"threshold_uncertainty_score":0.01596516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958976081070521,"score_gpt":0.2948798114966598,"score_spread":0.2752900506859546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}