{"id":"W2597570904","doi":"10.1021/acscatal.6b03051","title":"Pretransfer Editing in Threonyl-tRNA Synthetase: Roles of Differential Solvent Accessibility and Intermediate Stabilization","year":2017,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Campus France; Natural Sciences and Engineering Research Council of Canada; Mitacs; Université de Lorraine","keywords":"Aminoacylation; Aminoacyl tRNA synthetase; Chemistry; Active site; Transfer RNA; Stereochemistry; Catalysis; Combinatorial chemistry; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636134,0.0001137645,0.0001931086,0.00004131523,0.00009459865,0.00004834679,0.0002622682,0.0001104743,0.00002502688],"category_scores_gemma":[0.0002649815,0.0001004113,0.00006777154,0.00002673217,0.0001119584,0.00001681963,0.000162199,0.00004697653,6.687479e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006912609,"about_ca_system_score_gemma":0.00001764006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004866538,"about_ca_topic_score_gemma":0.0004674884,"domain_scores_codex":[0.9991476,0.00005525071,0.0002437114,0.0003011079,0.000114061,0.0001382834],"domain_scores_gemma":[0.9992113,0.00001524347,0.0001509788,0.0005393925,0.00004340904,0.00003968901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005352189,0.00005853048,0.04051846,0.00005457051,0.00004690843,8.753146e-7,0.0001275955,0.000003729602,0.9364104,0.00002440929,0.000004151527,0.02269691],"study_design_scores_gemma":[0.0002449685,0.00004832137,0.05179413,0.00004070197,0.00004859535,6.795684e-7,0.00007681027,0.00007113238,0.9473011,0.000245944,0.00002825718,0.00009937971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959468,0.0002784647,0.003377596,0.00005322947,0.00008325816,0.0001401478,0.00003489726,0.00000377089,0.00008184205],"genre_scores_gemma":[0.9994507,0.0002205591,0.00008092151,0.000007389263,0.00008512197,0.00002350881,0.00009985806,0.00001093455,0.0000209774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02259753,"threshold_uncertainty_score":0.4094653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127887429982312,"score_gpt":0.2604173701517165,"score_spread":0.2491384958518933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}