{"id":"W2597614090","doi":"10.1007/s10549-017-4203-y","title":"Cardiac safety, efficacy, and correlation of serial serum HER2-extracellular domain shed antigen measurement with the outcome of the combined trastuzumab plus CMF in women with HER2-positive metastatic breast cancer: results from the EORTC 10995 phase II study","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; F. Hoffmann-La Roche","keywords":"Trastuzumab; Medicine; Internal medicine; Breast cancer; Metastatic breast cancer; Chemotherapy; Cardiotoxicity; Oncology; Cancer; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002606234,0.0006962987,0.00098923,0.0002175614,0.0001551244,0.0006550006,0.0003823624,0.0006772017,0.0007175458],"category_scores_gemma":[0.003077188,0.0002578908,0.0006756178,0.0002890388,0.000543093,0.000545393,0.0001970176,0.001181505,0.0001826422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004646901,"about_ca_system_score_gemma":0.0003735138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003452042,"about_ca_topic_score_gemma":0.0005018261,"domain_scores_codex":[0.9991871,0.0004340204,0.00004307765,0.0001340391,0.0001201188,0.00008172909],"domain_scores_gemma":[0.9985477,0.0005722401,0.000403618,0.0001801379,0.00007504403,0.0002212571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.664348,0.005616879,0.2023637,0.0002739723,0.003720528,0.0002768389,0.0001261666,0.003097878,0.02369251,0.0002587811,0.001435615,0.0947891],"study_design_scores_gemma":[0.06686264,0.2155714,0.6954495,0.000064883,0.004142805,0.0006511549,0.0001052651,0.005852219,0.00806487,0.000685178,0.002476341,0.00007370109],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962839,0.002135285,0.0002151006,0.0001617131,0.00003516418,0.00003829604,0.0002292444,0.00001186406,0.0008894549],"genre_scores_gemma":[0.9986708,0.000350032,0.00009915142,0.0001376628,0.0001014096,0.00002610162,0.0003599662,0.000004546972,0.000250316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002606234,"threshold_uncertainty_score":0.01378322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06190435784903774,"score_gpt":0.3730070044196442,"score_spread":0.3111026465706065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}