{"id":"W2597647786","doi":"10.1126/science.aan1467","title":"Costimulation, a surprising connection for immunotherapy","year":2017,"lang":"en","type":"letter","venue":"Science","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Immunotherapy; Connection (principal bundle); Sensitivity (control systems); Medicine; Immunology; Immune system; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001993212,0.0005208433,0.000901985,0.0003172328,0.0009064931,0.002099454,0.0006617898,0.0061256,0.003812085],"category_scores_gemma":[0.007628877,0.0002088257,0.0003852318,0.0002102184,0.003044174,0.00270912,0.001043379,0.01534207,0.001826145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001508039,"about_ca_system_score_gemma":0.0006402481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001873955,"about_ca_topic_score_gemma":0.0002723353,"domain_scores_codex":[0.9986315,0.0004993485,0.0000887737,0.0002076275,0.0004078013,0.000164807],"domain_scores_gemma":[0.9959484,0.002845905,0.0001892894,0.000337332,0.0004232826,0.000255852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001127241,0.0003316178,0.004204458,0.0004848716,0.0001284724,0.005647466,0.0003018105,0.0008175427,0.02176899,0.1132204,0.6566777,0.1952895],"study_design_scores_gemma":[0.000485083,0.0005470766,0.001740819,0.000191413,0.00006603255,0.005161198,0.0004111094,0.002195888,0.00945017,0.1335566,0.8461334,0.00006116922],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01052966,0.02466304,0.002219328,0.9300594,0.02305547,0.00002940053,0.00007206907,0.00009770017,0.009273862],"genre_scores_gemma":[0.2574502,0.02575922,0.003760108,0.5410113,0.1477093,0.0001756446,0.0001802598,0.00009875523,0.0238553],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0061256,"threshold_uncertainty_score":0.01275265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0404615149108119,"score_gpt":0.3476341916375922,"score_spread":0.3071726767267803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}