{"id":"W2597648644","doi":"10.1200/jco.2017.35.6_suppl.146","title":"PACIFIC trial: A randomized phase II study of apatorsen and abiraterone in patients (Pts) with metastatic castration-resistant prostate cancer (mCRPC) who have had PSA progression while receiving abiraterone (ABI).","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université de Montréal; CancerCare Manitoba; BC Cancer Agency","funders":"","keywords":"Medicine; Prostate cancer; Clinical endpoint; Internal medicine; Adverse effect; Abiraterone acetate; Androgen deprivation therapy; Oncology; Urology; Progression-free survival; Cancer; Phases of clinical research; Randomized controlled trial; Clinical trial; Gastroenterology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000849238,0.001748086,0.00236742,0.0003677497,0.0003508153,0.0007667591,0.0008547996,0.001013459,0.01088323],"category_scores_gemma":[0.001295102,0.0006377675,0.000912799,0.0004570688,0.0009929612,0.0009623638,0.0004838975,0.002557906,0.001157775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005290383,"about_ca_system_score_gemma":0.001692863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406319,"about_ca_topic_score_gemma":0.003320841,"domain_scores_codex":[0.9996933,0.0001564898,0.00001484608,0.00004881985,0.00003722486,0.00004938477],"domain_scores_gemma":[0.999507,0.00009420369,0.0001054072,0.00003685272,0.00003205681,0.000224547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9590748,0.007392698,0.00124791,0.0007414672,0.0006189409,0.00006839904,0.00007238584,0.0004428356,0.003050118,0.0002168036,0.001741306,0.02533243],"study_design_scores_gemma":[0.9366288,0.05915432,0.00208957,0.00002284125,0.0002567732,0.0000605113,0.00003021302,0.0003000844,0.0002021741,0.0001797567,0.001064675,0.00001012176],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786105,0.003479248,0.0008240202,0.0008503299,0.0004082216,0.008858575,0.001990338,0.0002369112,0.004741904],"genre_scores_gemma":[0.9583596,0.00517953,0.003687599,0.002061246,0.0005668745,0.01657274,0.003779704,0.00005721239,0.009735471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01088323,"threshold_uncertainty_score":0.03640795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08849816467571489,"score_gpt":0.470523404404511,"score_spread":0.3820252397287961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}