{"id":"W2597720589","doi":"10.1093/hmg/ddx122","title":"Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Biology; Gene knockdown; Pathogenesis; Cell polarity; Mutant; Missense mutation; Cell biology; Mutation; Genetics; Cell; Molecular biology; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008785206,0.0004004698,0.0002243224,0.0003784912,0.000302946,0.0002050919,0.0001230645,0.0002995092,0.001299917],"category_scores_gemma":[0.0001226016,0.0001017954,0.0001864651,0.0001510584,0.0002471049,0.00009549347,0.0002554759,0.0003680196,0.0002867193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037523,"about_ca_system_score_gemma":0.0001852973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000480495,"about_ca_topic_score_gemma":0.0006583045,"domain_scores_codex":[0.9999126,0.00001267896,0.000007626796,0.00002488677,0.00002680797,0.00001538343],"domain_scores_gemma":[0.9999075,0.000008430809,0.00003974478,0.000004778437,0.000006697741,0.00003289501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001525011,0.00001959628,0.004849055,0.00004557879,0.00001487026,0.002037426,0.00004744387,0.0001345566,0.9883676,0.0001461686,0.0001143017,0.004071042],"study_design_scores_gemma":[0.00005902838,0.0005383858,0.2218761,0.00003887877,0.0001233023,0.03280155,0.0002242045,0.002893593,0.7323148,0.0004242722,0.008680894,0.00002508905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954299,0.001792301,0.001644699,0.00009029136,0.000008953546,0.00001204582,0.000261339,0.00007469849,0.0006858312],"genre_scores_gemma":[0.9976768,0.0005735451,0.0007216632,0.0000306601,0.000005127541,0.000008276533,0.0002228058,0.00001275694,0.0007484626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299917,"threshold_uncertainty_score":0.004348636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400381485118747,"score_gpt":0.2739158405028703,"score_spread":0.2599120256516828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}