{"id":"W2597789916","doi":"10.1212/wnl.80.7_supplement.p07.096","title":"Combined MRI Measure of Active Lesions and Brain Atrophy as a Surrogate for Disability in Multiple Sclerosis: A Meta-Analysis of Randomized Trials (P07.096)","year":2013,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Multiple sclerosis; Atrophy; Meta-analysis; Medicine; Surrogate endpoint; Randomized controlled trial; Physical medicine and rehabilitation; Physical therapy; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0293512,0.003148401,0.01440171,0.00190625,0.0005442937,0.003416641,0.001876022,0.003702557,0.003702634],"category_scores_gemma":[0.0493985,0.001137938,0.03371135,0.002518022,0.001054498,0.002119573,0.001443539,0.003362791,0.0003711715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008401865,"about_ca_system_score_gemma":0.0009052602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381965,"about_ca_topic_score_gemma":0.002119471,"domain_scores_codex":[0.9700657,0.02268021,0.003138787,0.002507206,0.001219626,0.0003884275],"domain_scores_gemma":[0.959858,0.03138468,0.00502175,0.002046272,0.001152692,0.0005366186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0522637,0.00005748617,0.008428684,0.02086354,0.9131466,0.00005941197,0.00002734803,0.0004985933,0.000338188,0.0001202013,0.0004402623,0.003756],"study_design_scores_gemma":[0.0173912,0.001744537,0.005956008,0.001110747,0.9717207,0.00009239218,0.00002431983,0.0006638912,0.0001997617,0.0004125893,0.0006565566,0.00002741705],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1736442,0.8101553,0.006468379,0.001726561,0.002131709,0.001090009,0.00314337,0.0002208935,0.001419585],"genre_scores_gemma":[0.9458233,0.04349957,0.00524444,0.001233331,0.001014506,0.001211007,0.001257533,0.00007059999,0.000645661],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0293512,"threshold_uncertainty_score":0.1552258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2528190878013531,"score_gpt":0.3774999988305685,"score_spread":0.1246809110292154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}