{"id":"W2597919924","doi":"10.1212/nxi.0000000000000340","title":"Dimethyl fumarate–induced lymphopenia in MS due to differential T-cell subset apoptosis","year":2017,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"McGill University","keywords":"Apoptosis; CD8; In vivo; T cell; Cell; Programmed cell death; In vitro; Cytotoxic T cell; Biology; Immunology; Chemistry; Molecular biology; Cell biology; Immune system; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003433229,0.0005776759,0.001106009,0.0008408764,0.0007796473,0.0001483279,0.0009951713,0.0004483164,0.000244148],"category_scores_gemma":[0.002446672,0.0005726621,0.0002157629,0.0003133348,0.0004557628,0.0003964202,0.00104754,0.001295674,0.0005623623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008072864,"about_ca_system_score_gemma":0.0001498928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003743824,"about_ca_topic_score_gemma":0.00028429,"domain_scores_codex":[0.9952634,0.0008107321,0.0009113016,0.001315675,0.0005063792,0.001192522],"domain_scores_gemma":[0.9964225,0.0004755559,0.000474893,0.002138223,0.0002292984,0.0002595728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002822574,0.0003030306,0.02897921,0.00005235206,0.00004798876,0.0004899279,0.000208341,0.00002148755,0.9572793,0.00004265425,0.0005389898,0.009214118],"study_design_scores_gemma":[0.004847052,0.001650509,0.8506939,0.00002320989,0.00005310285,0.0001842745,0.000008545362,0.0006477576,0.1402337,0.0000357224,0.001332221,0.0002900091],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731847,0.00002741778,0.00002021654,0.0210024,0.001432642,0.001767494,0.00001864668,0.000180773,0.002365695],"genre_scores_gemma":[0.9974951,0.0002673065,0.000052091,0.001263808,0.0002270224,0.0002558848,0.00003829468,0.0001010375,0.0002994947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8217148,"threshold_uncertainty_score":0.9996725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0382436734497531,"score_gpt":0.3056810282743139,"score_spread":0.2674373548245608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}