{"id":"W2597919924","doi":"10.1212/nxi.0000000000000340","title":"Dimethyl fumarate–induced lymphopenia in MS due to differential T-cell subset apoptosis","year":2017,"lang":"en","type":"article","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"McGill University","keywords":"Apoptosis; CD8; In vivo; T cell; Cell; Programmed cell death; In vitro; Cytotoxic T cell; Biology; Immunology; Chemistry; Molecular biology; Cell biology; Immune system; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004925829,0.0002400526,0.0003267851,0.0002594782,0.0001353268,0.0001787024,0.0001185657,0.0001574752,0.0008505548],"category_scores_gemma":[0.0006583943,0.0001390507,0.0002453714,0.000132521,0.0001601483,0.0001273271,0.0001480621,0.0002208111,0.0001211887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002610454,"about_ca_system_score_gemma":0.0001553948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003910105,"about_ca_topic_score_gemma":0.0005654403,"domain_scores_codex":[0.9997935,0.00009294503,0.00002257817,0.0000338859,0.00003277616,0.00002444591],"domain_scores_gemma":[0.9997495,0.0001023524,0.00008328361,0.00002250821,0.00002190886,0.00002040016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01142188,0.0002948377,0.1901755,0.0003969902,0.0003135079,0.001730395,0.0003036471,0.003042496,0.7502974,0.0002477336,0.0002461261,0.04152939],"study_design_scores_gemma":[0.0005387875,0.01455704,0.6039255,0.00007433994,0.0007696176,0.01225143,0.000252149,0.01325114,0.3504716,0.0005256988,0.003355164,0.00002749828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982128,0.0006740438,0.0007404707,0.00001453532,0.000003924055,0.00001375821,0.0000751686,0.00001561606,0.0002498047],"genre_scores_gemma":[0.9994727,0.00009029266,0.0002526307,0.00001170135,0.000003455229,0.000008374555,0.00006228081,0.000002292128,0.00009627052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008505548,"threshold_uncertainty_score":0.002845407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0382436734497531,"score_gpt":0.3056810282743139,"score_spread":0.2674373548245608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}