{"id":"W2597924550","doi":"10.1182/blood.v128.22.230.230","title":"Results of the Phase 3 Study of Lenalidomide Versus Placebo As Maintenance Therapy Following Second-Line Treatment for Patients with Chronic Lymphocytic Leukemia (the CONTINUUM Trial)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Internal medicine; Lenalidomide; Bendamustine; Maintenance therapy; Clinical endpoint; Progression-free survival; Oncology; Randomization; IGHV@; Chronic lymphocytic leukemia; Minimal residual disease; Neutropenia; Phases of clinical research; Randomized controlled trial; Clinical trial; Leukemia; Multiple myeloma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006151052,0.0002945916,0.0006959091,0.00007246614,0.0001172823,0.00001191721,0.00037066,0.00008611483,0.00003223236],"category_scores_gemma":[0.0007828671,0.0001159217,0.0003232586,0.0002606724,0.0002135937,0.00006705655,0.0000713203,0.0000822187,0.000005702624],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.01774352,"about_ca_system_score_gemma":0.01509208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008213879,"about_ca_topic_score_gemma":0.0007364139,"domain_scores_codex":[0.9974097,0.0001848506,0.0007332462,0.0004528885,0.0007242718,0.0004950405],"domain_scores_gemma":[0.996322,0.001651927,0.0004600533,0.001179378,0.0002810789,0.0001055207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9640983,0.008303027,0.0003681701,0.0001122814,0.004263145,0.00005218477,0.001947874,0.00002551148,0.006629824,0.00001776464,0.0004917543,0.0136902],"study_design_scores_gemma":[0.8754995,0.04214376,0.0001968739,0.0003499301,0.0006812401,0.000008728406,0.0002512631,0.0001037787,0.0792689,0.00001113219,0.001353927,0.0001309007],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907492,0.0002805364,0.00000858711,0.0001116299,0.000297096,0.00820098,0.00008895396,0.00002362651,0.000239365],"genre_scores_gemma":[0.9964482,0.0000680324,0.00002868822,0.00002636635,0.0001900248,0.0005769444,0.0000125731,0.00005082526,0.002598361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08859871,"threshold_uncertainty_score":0.9904914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0315961884502852,"score_gpt":0.3215981640664695,"score_spread":0.2900019756161843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}