{"id":"W2597924550","doi":"10.1182/blood.v128.22.230.230","title":"Results of the Phase 3 Study of Lenalidomide Versus Placebo As Maintenance Therapy Following Second-Line Treatment for Patients with Chronic Lymphocytic Leukemia (the CONTINUUM Trial)","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Internal medicine; Lenalidomide; Bendamustine; Maintenance therapy; Clinical endpoint; Progression-free survival; Oncology; Randomization; IGHV@; Chronic lymphocytic leukemia; Minimal residual disease; Neutropenia; Phases of clinical research; Randomized controlled trial; Clinical trial; Leukemia; Multiple myeloma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002500875,0.001138978,0.002268483,0.0003003213,0.0004570216,0.00133068,0.0009496975,0.001351798,0.00577199],"category_scores_gemma":[0.001773468,0.000379752,0.001405073,0.0003189919,0.0007973311,0.0009764992,0.000475338,0.002686902,0.0007606217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009594155,"about_ca_system_score_gemma":0.001267319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007747691,"about_ca_topic_score_gemma":0.001592399,"domain_scores_codex":[0.9992054,0.0005267913,0.00003759583,0.0001059873,0.00004853339,0.00007574545],"domain_scores_gemma":[0.9989214,0.0002705418,0.0002872048,0.00008603014,0.00005622378,0.0003786171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.975373,0.006787552,0.001093057,0.0002179738,0.0005370468,0.00003247504,0.00004047289,0.0002515576,0.001890659,0.00008564237,0.001142861,0.01254767],"study_design_scores_gemma":[0.916871,0.07880423,0.002652782,0.00002674789,0.0002678068,0.00003461794,0.00001799893,0.0002723771,0.0002399508,0.0001295487,0.0006736472,0.000009436556],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874515,0.003824699,0.0004545912,0.000833998,0.0003638745,0.003062943,0.001574271,0.0001066677,0.002327475],"genre_scores_gemma":[0.9882956,0.001479405,0.001136455,0.001267396,0.0003737625,0.003685899,0.001771156,0.00002083427,0.001969595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00577199,"threshold_uncertainty_score":0.01930922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0315961884502852,"score_gpt":0.3215981640664695,"score_spread":0.2900019756161843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}