{"id":"W2598027697","doi":"10.1371/journal.pone.0174019","title":"Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; University of Cincinnati","keywords":"Inflammation; Transgene; Genetically modified mouse; Cardiomyopathy; Fibrosis; Cancer research; Ventricular remodeling; Medicine; Cardiology; Heart failure; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619548,0.0009863446,0.0002987267,0.0005757221,0.0001802044,0.0002548173,0.0002274856,0.0005939674,0.002046448],"category_scores_gemma":[0.0001098831,0.0002937952,0.0003431667,0.0002228709,0.0003923082,0.000241464,0.0003065764,0.0007277348,0.0005611139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729768,"about_ca_system_score_gemma":0.0001559853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002410473,"about_ca_topic_score_gemma":0.0005641932,"domain_scores_codex":[0.9998428,0.00001322736,0.00001853057,0.00005092564,0.00004155363,0.00003293567],"domain_scores_gemma":[0.9997268,0.00002587415,0.0001289835,0.00001311632,0.00001530313,0.00008990313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007561199,0.00002898312,0.0002834445,0.0000185828,0.000005544253,0.0001605808,0.00001432485,0.0000230633,0.9990299,0.00003908337,0.00002816297,0.0002926705],"study_design_scores_gemma":[0.0001609536,0.001116339,0.02830156,0.00003728773,0.000119827,0.004496521,0.0001038867,0.00131438,0.9593491,0.0001651038,0.004809749,0.00002529097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932868,0.0007252069,0.003937247,0.0001394779,0.0000499093,0.0000545986,0.0008021503,0.0002176428,0.0007869243],"genre_scores_gemma":[0.9829284,0.0009749884,0.005337574,0.0001462719,0.00004007701,0.0002078182,0.002158246,0.00009259205,0.008113997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046448,"threshold_uncertainty_score":0.006846011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03481288108812843,"score_gpt":0.2343562971133143,"score_spread":0.1995434160251858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}