{"id":"W2598407279","doi":"10.1200/jco.2013.31.15_suppl.tps2618","title":"A phase Ib study of combined angiogenesis blockade with REGN910 (SAR307746), a selective monoclonal antibody (MAb) against angiopoietin-2 (Ang2) and ziv-aflibercept in patients with advanced solid tumor malignancies.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Aflibercept; Placental growth factor; Angiogenesis; Blockade; Bevacizumab; Oncology; Angiopoietin receptor; Cohort; Internal medicine; Cancer; Cancer research; Pharmacology; Vascular endothelial growth factor; Receptor; Chemotherapy; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001552973,0.002083742,0.001809326,0.0006697815,0.0003934811,0.0009603181,0.001290739,0.001413074,0.003418054],"category_scores_gemma":[0.0006752004,0.0008614628,0.001229561,0.0005459847,0.001099746,0.001194509,0.0004189902,0.003661246,0.00125721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001109007,"about_ca_system_score_gemma":0.001968543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029142,"about_ca_topic_score_gemma":0.002129932,"domain_scores_codex":[0.9994295,0.000257644,0.00002532082,0.0001044223,0.00006143018,0.0001215097],"domain_scores_gemma":[0.9992755,0.00008920789,0.0001611469,0.0000716103,0.00004390905,0.0003585282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5185202,0.2396987,0.004690191,0.001047496,0.001770097,0.0003861228,0.0004155258,0.006028663,0.1086297,0.0006162316,0.006130552,0.1120666],"study_design_scores_gemma":[0.2912928,0.6927459,0.004789581,0.00002582965,0.0003100154,0.0003578434,0.00005789736,0.001205281,0.006263398,0.0001886119,0.002734343,0.00002849146],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873812,0.002276731,0.00127196,0.0005586335,0.0002050593,0.003884819,0.001308488,0.0001910696,0.002922046],"genre_scores_gemma":[0.9851693,0.001896418,0.0027711,0.0008012894,0.0002069278,0.003680901,0.002439037,0.00004670478,0.002988302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003418054,"threshold_uncertainty_score":0.01143456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981538037344068,"score_gpt":0.365267283409167,"score_spread":0.3454519030357264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}