{"id":"W2598412837","doi":"10.3174/ajnr.a5143","title":"Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with<sup>1</sup>H-MRS and Pittsburgh Compound-B PET","year":2017,"lang":"en","type":"article","venue":"American Journal of Neuroradiology","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; National Center for Research Resources; Australian Government; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Glutathione; Amyloidosis; Internal medicine; Pathology; Positron emission tomography; Amyloid (mycology); Biomarker; Oxidative stress; Oncology; Nuclear medicine; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0007645768,0.000256106,0.0006442522,0.0002379763,0.0002009132,0.00003545656,0.0003493618,0.0001536535,0.000004580058],"category_scores_gemma":[0.00131394,0.0002267443,0.00004611741,0.0001362851,0.002809626,0.00002690437,0.0001586171,0.0008663385,4.061135e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003499834,"about_ca_system_score_gemma":0.0001714368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002147109,"about_ca_topic_score_gemma":0.0002966781,"domain_scores_codex":[0.9972134,0.001114825,0.0006563009,0.0004835798,0.000117181,0.0004147255],"domain_scores_gemma":[0.9980889,0.0004335913,0.0006909207,0.000409125,0.0001046241,0.0002728651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001840385,0.0001085384,0.9749512,0.00001660773,0.00006160511,0.000503359,0.0006331778,0.0002245998,0.02012465,0.00004318475,0.0003813166,0.001111354],"study_design_scores_gemma":[0.003212105,0.003693494,0.9852107,0.0000863271,0.00001916055,0.005397589,0.0009729054,0.0004249999,0.0003255039,0.0001385954,0.0002639903,0.0002545976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953454,0.0003759428,0.0001115826,0.003826467,0.0000983364,0.0001876498,0.000007073927,0.000005793107,0.00004175431],"genre_scores_gemma":[0.9971804,0.0003668304,0.0009649447,0.001315514,0.0001190522,0.000008807994,0.000005765518,0.00002950418,0.000009183656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01979914,"threshold_uncertainty_score":0.9999042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933447974841557,"score_gpt":0.2610171176709414,"score_spread":0.2416826379225258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}