{"id":"W2598412837","doi":"10.3174/ajnr.a5143","title":"Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with<sup>1</sup>H-MRS and Pittsburgh Compound-B PET","year":2017,"lang":"en","type":"article","venue":"American Journal of Neuroradiology","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; National Center for Research Resources; Australian Government; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Glutathione; Amyloidosis; Internal medicine; Pathology; Positron emission tomography; Amyloid (mycology); Biomarker; Oxidative stress; Oncology; Nuclear medicine; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003350858,0.0002869985,0.0002056118,0.0003867473,0.0001975569,0.0003632715,0.0001244001,0.0004205177,0.0007450819],"category_scores_gemma":[0.0006955641,0.0002507836,0.0001428494,0.0003224974,0.000235326,0.0002406587,0.0002275555,0.000289933,0.0001196536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098163,"about_ca_system_score_gemma":0.000103955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002201786,"about_ca_topic_score_gemma":0.002546993,"domain_scores_codex":[0.99993,0.00002068579,0.000005905944,0.000020356,0.00001036973,0.00001262721],"domain_scores_gemma":[0.9997503,0.00005020323,0.0001012986,0.00002598952,0.0000252333,0.00004695549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001858003,0.0001369194,0.9869545,0.0000203077,0.0001647125,0.0001759552,0.0001580533,0.00008361567,0.007755117,0.00001551302,0.00005121121,0.002626144],"study_design_scores_gemma":[0.00001289101,0.0002986006,0.998497,0.000001591914,0.00002826747,0.0002184823,0.0000763649,0.0002086851,0.00058371,0.00003649792,0.0000359415,0.000001838565],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996604,0.0001016967,0.00006971156,0.00001010733,8.473065e-7,0.000003728543,0.00006452679,0.000002226931,0.00008687691],"genre_scores_gemma":[0.999678,0.00004512532,0.0001173352,0.00001653629,0.000002235224,0.000004395421,0.00006163661,7.784971e-7,0.00007386023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002201786,"threshold_uncertainty_score":0.004377961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933447974841557,"score_gpt":0.2610171176709414,"score_spread":0.2416826379225258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}