{"id":"W2598466000","doi":"10.1016/j.vph.2017.03.002","title":"NOX2, NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells","year":2017,"lang":"en","type":"article","venue":"Vascular Pharmacology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"NOX4; Mitochondrial ROS; NADPH oxidase; Reactive oxygen species; Cell biology; Mitochondrion; Protein kinase B; Chemistry; Signal transduction; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003172924,0.0003192787,0.0001927126,0.0002385724,0.0003839089,0.0006734771,0.0002965488,0.0003109824,0.001332927],"category_scores_gemma":[0.0002162599,0.0001545622,0.0002467979,0.0001754097,0.0002540869,0.0006436813,0.000370472,0.0005702478,0.0002008946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005067811,"about_ca_system_score_gemma":0.0004485165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000592162,"about_ca_topic_score_gemma":0.0006862767,"domain_scores_codex":[0.9998009,0.00004387444,0.000009346477,0.00002521526,0.00005786402,0.00006295941],"domain_scores_gemma":[0.9998868,0.000008080523,0.00002757585,0.00000857425,0.00002515205,0.00004388633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001122656,0.0002512374,0.006062613,0.0001631227,0.00005511416,0.0004951372,0.0001169701,0.0004809119,0.962811,0.008528997,0.0008072733,0.01910502],"study_design_scores_gemma":[0.0001304235,0.0007445375,0.1086813,0.00003724113,0.0001516241,0.002049547,0.0006441557,0.01232615,0.8386859,0.007467792,0.02904836,0.00003289007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661896,0.01040657,0.01404338,0.001723815,0.0002168625,0.00005553335,0.0002425787,0.0001239706,0.006997672],"genre_scores_gemma":[0.9908617,0.002153439,0.002097908,0.0001587732,0.00006208795,0.0000283896,0.0001585108,0.00001126179,0.004467873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332927,"threshold_uncertainty_score":0.004459143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608503366669199,"score_gpt":0.2828953505582716,"score_spread":0.2668103168915796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}