{"id":"W2598498016","doi":"10.1002/clc.22692","title":"Rationale and design of <scp>REDUCE‐IT</scp>: Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial","year":2017,"lang":"en","type":"article","venue":"Clinical Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Amarin Pharma; Amarin Corporation","keywords":"Medicine; Internal medicine; Myocardial infarction; Clinical endpoint; Residual risk; Triglyceride; Placebo; Ezetimibe; Statin; Hazard ratio; Randomized controlled trial; Cardiology; Cholesterol; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03680018,0.004660223,0.005807681,0.001677347,0.003323552,0.004382233,0.003276589,0.004589239,0.0244067],"category_scores_gemma":[0.02427627,0.003101781,0.002644235,0.001972117,0.004430262,0.002824903,0.001736076,0.007947094,0.01322669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002208063,"about_ca_system_score_gemma":0.01030958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464213,"about_ca_topic_score_gemma":0.003002413,"domain_scores_codex":[0.9792702,0.0128141,0.001508903,0.002463966,0.002464742,0.001478038],"domain_scores_gemma":[0.9930387,0.001678437,0.0009413298,0.000857416,0.001669859,0.001814205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.6604279,0.0205714,0.01381499,0.03170174,0.004487238,0.002171352,0.001443435,0.004134515,0.008555526,0.04229968,0.0920381,0.1183542],"study_design_scores_gemma":[0.6893126,0.04809954,0.01628598,0.009998286,0.004536247,0.0008490919,0.0005614904,0.005901481,0.002660887,0.03053733,0.1907924,0.0004646494],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01142094,0.006918056,0.00861626,0.005315129,0.002991664,0.9453009,0.007539826,0.000274427,0.01162273],"genre_scores_gemma":[0.02880624,0.001940942,0.01590385,0.005470587,0.00106494,0.941633,0.002561653,0.00004755834,0.002571194],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03680018,"threshold_uncertainty_score":0.1946203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1197287351014064,"score_gpt":0.3869967778816125,"score_spread":0.2672680427802061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}