{"id":"W2598696175","doi":"10.1182/blood-2016-11-747022","title":"Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Diffuse large B-cell lymphoma; Cell of origin; Biology; Gene expression profiling; Lymphoma; Cancer research; Profiling (computer programming); Cell; Computational biology; Genetics; Gene; Immunology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002929826,0.0001395277,0.0002388893,0.0006656072,0.0001875755,0.0007184545,0.0001597802,0.0003062635,0.001707684],"category_scores_gemma":[0.0006333698,0.000122741,0.0001539208,0.0004273759,0.0002184823,0.0002038584,0.0002192089,0.0003188423,0.0003772538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721054,"about_ca_system_score_gemma":0.0001604231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00107049,"about_ca_topic_score_gemma":0.002351103,"domain_scores_codex":[0.999665,0.00007756598,0.00002572611,0.00007705717,0.00008586606,0.00006866816],"domain_scores_gemma":[0.9996448,0.00009426971,0.00009128137,0.00003413763,0.00005633957,0.00007921048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002670647,0.0001580449,0.412224,0.0000511631,0.0001213131,0.0005532507,0.0001150327,0.0003489189,0.5579445,0.0001833789,0.0003326027,0.02529716],"study_design_scores_gemma":[0.00003618349,0.000534981,0.9282562,0.00001305934,0.0001196114,0.002634151,0.0003083114,0.001306666,0.06478748,0.0001711276,0.001822717,0.000009504824],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977692,0.0004843598,0.00023662,0.00005233131,0.000004603928,0.000009451639,0.0002952933,0.00001324845,0.001134818],"genre_scores_gemma":[0.9991572,0.00009985111,0.0001555076,0.00002788975,0.000003297207,0.00000319423,0.000252336,0.00000790955,0.000292762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001707684,"threshold_uncertainty_score":0.005712748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03171397729753282,"score_gpt":0.3348248998591481,"score_spread":0.3031109225616153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}