{"id":"W2598757413","doi":"10.1038/srep45466","title":"Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; University of Queensland; Australian Synchrotron; Ryerson University","keywords":"Conotoxin; Pharmacophore; Nicotinic agonist; Acetylcholine receptor; Nicotinic acetylcholine receptor; Chemistry; Pharmacology; Nicotinic Antagonist; Biology; Receptor; Biochemistry; Venom","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000181801,0.0002908375,0.0001954256,0.00009951523,0.0001745843,0.0003175963,0.0004446916,0.0003505343,0.001633601],"category_scores_gemma":[0.0002293131,0.0001217805,0.0002299279,0.00008862424,0.0004252772,0.0003188672,0.0002257415,0.0005471481,0.0003508964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005656465,"about_ca_system_score_gemma":0.0004025241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000560313,"about_ca_topic_score_gemma":0.0006116262,"domain_scores_codex":[0.9998997,0.00002224326,0.000008242109,0.00001526301,0.00003198853,0.0000225785],"domain_scores_gemma":[0.9999027,0.00001347696,0.00004831074,0.000005778529,0.00001080471,0.00001887961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001886637,0.0000612026,0.0005691606,0.0001315202,0.00001427624,0.0002808353,0.00003930861,0.00167159,0.9901175,0.00311379,0.0001169555,0.003695313],"study_design_scores_gemma":[0.0002156537,0.00204597,0.009516716,0.00006013324,0.00007816539,0.001300781,0.0002021236,0.007445327,0.9647299,0.004378328,0.009996863,0.00003003737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796293,0.005907272,0.007183368,0.0007322596,0.00004536955,0.00006011584,0.000121565,0.0000905014,0.006230255],"genre_scores_gemma":[0.9955364,0.001783864,0.00123633,0.0001532145,0.00001145887,0.00001649093,0.0001145828,0.00000657556,0.001140935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633601,"threshold_uncertainty_score":0.005464971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343881090837587,"score_gpt":0.3132794699690675,"score_spread":0.2898406590606916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}