{"id":"W2598764697","doi":"10.1038/srep44826","title":"Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Fudan University; National Natural Science Foundation of China","keywords":"Isocitrate lyase; Acetylation; Lysine; Biochemistry; Glyoxylate cycle; Enzyme; Malate synthase; Metabolism; Biology; Chemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004782121,0.00008487426,0.0001449827,0.00004921944,0.00006743698,0.00004526644,0.0001401685,0.0001212313,0.00000842288],"category_scores_gemma":[0.0001871092,0.00008004573,0.00008335325,0.00007890702,0.0002532886,0.000008981887,0.0001135152,0.00005697227,2.315894e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001011529,"about_ca_system_score_gemma":0.00007224439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002497588,"about_ca_topic_score_gemma":0.00003235518,"domain_scores_codex":[0.9987726,0.00003788013,0.0003331897,0.0003869367,0.0002619225,0.0002074261],"domain_scores_gemma":[0.9987578,0.00000227899,0.0003042874,0.0007221016,0.000148513,0.00006504512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002402591,0.00006121898,0.01290076,0.00002952683,0.00001459649,0.000004371286,0.0000326569,0.0000193602,0.9859011,0.000007351402,0.0003779861,0.0006270806],"study_design_scores_gemma":[0.0001612361,0.00001850381,0.04527435,0.00001452328,0.000008810284,0.000004566453,0.000008237183,0.0002024461,0.9525325,0.0002311022,0.001467673,0.00007609001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982269,0.0003192214,0.00004897713,0.00009133587,0.0005402332,0.0001575698,0.00001043331,0.000002331919,0.0006030375],"genre_scores_gemma":[0.9992389,0.00002988829,0.000095188,0.000004261252,0.00003206003,0.000006850288,0.0002135595,0.000008023703,0.0003712856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0333686,"threshold_uncertainty_score":0.326417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009467241924578824,"score_gpt":0.2617145294113996,"score_spread":0.2522472874868208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}