{"id":"W2598764697","doi":"10.1038/srep44826","title":"Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Fudan University; National Natural Science Foundation of China","keywords":"Isocitrate lyase; Acetylation; Lysine; Biochemistry; Glyoxylate cycle; Enzyme; Malate synthase; Metabolism; Biology; Chemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009774065,0.000245627,0.0001878481,0.0001349648,0.0001165199,0.0002084641,0.0001592324,0.000191485,0.0003463794],"category_scores_gemma":[0.00008755717,0.0001129971,0.0001724827,0.0001492054,0.0001724911,0.0001153094,0.0001495725,0.0002600022,0.0002161802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630381,"about_ca_system_score_gemma":0.0001322543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000861215,"about_ca_topic_score_gemma":0.00109869,"domain_scores_codex":[0.9999236,0.00001405554,0.000008117478,0.0000168786,0.00001840603,0.00001902714],"domain_scores_gemma":[0.9999323,0.00000532438,0.00002249282,0.00001074914,0.00001150903,0.00001759295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004145577,0.000005953015,0.000279539,0.00000979574,0.000001210826,0.00001607513,0.000004235215,0.00001708482,0.9992943,0.00001107846,0.000004309199,0.0003150099],"study_design_scores_gemma":[0.00001466987,0.0001718219,0.01814042,0.000004120928,0.00001403986,0.000287865,0.00002648942,0.0008447415,0.9795899,0.00006237503,0.0008386254,0.000004918023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970828,0.001317076,0.001034247,0.00007306488,0.00001629065,0.000007050177,0.00009729426,0.00002096139,0.0003512076],"genre_scores_gemma":[0.9981673,0.0004487455,0.0008357204,0.00002707707,0.000004781566,0.000005815163,0.0001514306,0.000006877749,0.0003523101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000861215,"threshold_uncertainty_score":0.001908481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009467241924578824,"score_gpt":0.2617145294113996,"score_spread":0.2522472874868208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}