{"id":"W2598829434","doi":"10.1002/cbic.201700115","title":"A Tandem Enzymatic sp<sup>2</sup>‐C‐Methylation Process: Coupling in Situ S‐Adenosyl‐<scp>l</scp>‐Methionine Formation with Methyl Transfer","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"Engineering and Physical Sciences Research Council; GlaxoSmithKline","keywords":"Methylation; Tandem; Methyltransferase; Chemistry; In situ; Alkylation; Methionine; Enzyme; Stereochemistry; Streptomyces; Organic chemistry; Biochemistry; Bacteria; DNA; Amino acid; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008361627,0.0003439272,0.0004359559,0.0001502469,0.0005345219,0.0001250801,0.0004207755,0.000534774,0.0001551949],"category_scores_gemma":[0.0008121983,0.0003038617,0.000108352,0.0002648635,0.0002281262,0.0006933067,0.0000550328,0.001049338,0.00007589417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631238,"about_ca_system_score_gemma":0.0001084167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001721591,"about_ca_topic_score_gemma":0.00003031753,"domain_scores_codex":[0.9981571,0.00006116065,0.0005227799,0.0004431163,0.0002815865,0.0005342938],"domain_scores_gemma":[0.9983597,0.000594589,0.0002180769,0.0004129155,0.0001959044,0.0002188489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002535513,0.000764896,0.006969148,0.0006422776,0.0002413868,0.0000341846,0.007897439,0.005121394,0.9718133,0.0004495665,0.001036605,0.004776238],"study_design_scores_gemma":[0.002534289,0.00008746632,0.001028326,0.0001258313,0.0001557762,0.00002309004,0.001314622,0.03093313,0.9567221,0.0005524807,0.006324742,0.0001980761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849762,0.0005260083,0.001477984,0.000478814,0.0001122989,0.0006267894,0.00001212466,0.0001075354,0.01168223],"genre_scores_gemma":[0.9979881,0.0002291633,0.0003174558,0.0002667465,0.0002119489,0.0001782652,0.00008655555,0.00004174676,0.0006799865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02581174,"threshold_uncertainty_score":0.9999413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07165818061616787,"score_gpt":0.3846393149279286,"score_spread":0.3129811343117608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}