{"id":"W2598829434","doi":"10.1002/cbic.201700115","title":"A Tandem Enzymatic sp<sup>2</sup>‐C‐Methylation Process: Coupling in Situ S‐Adenosyl‐<scp>l</scp>‐Methionine Formation with Methyl Transfer","year":2017,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"Engineering and Physical Sciences Research Council; GlaxoSmithKline","keywords":"Methylation; Tandem; Methyltransferase; Chemistry; In situ; Alkylation; Methionine; Enzyme; Stereochemistry; Streptomyces; Organic chemistry; Biochemistry; Bacteria; DNA; Amino acid; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882259,0.0004374656,0.0002543758,0.0001108701,0.000173868,0.0002326411,0.0003469652,0.0003327638,0.001255425],"category_scores_gemma":[0.0001347357,0.0002228698,0.0002246849,0.0001583289,0.0002229474,0.0001971476,0.0003691379,0.0004727996,0.0008865462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002968608,"about_ca_system_score_gemma":0.0002862348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005155393,"about_ca_topic_score_gemma":0.0007804255,"domain_scores_codex":[0.9998677,0.0000194091,0.000006639855,0.0000443675,0.00003480141,0.00002709207],"domain_scores_gemma":[0.9999235,0.00001306986,0.0000205028,0.000018263,0.00001170439,0.00001304897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002896403,0.000005961035,0.00002426789,0.000024207,0.000004037999,0.00002782892,0.000007827574,0.00005523052,0.9979978,0.00008459805,0.00004820352,0.00169104],"study_design_scores_gemma":[0.000004141156,0.00004945986,0.0001757762,7.315969e-7,0.000003973732,0.0001013695,0.00000308881,0.0001944647,0.997838,0.00001988024,0.001606451,0.000002752626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9150296,0.002201751,0.07440089,0.0002976792,0.00009989204,0.0001407441,0.0005923029,0.001003217,0.006233927],"genre_scores_gemma":[0.9664066,0.0006710967,0.02648088,0.00007789028,0.00001659171,0.00006588472,0.0003670362,0.00007103742,0.005842984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001255425,"threshold_uncertainty_score":0.004199803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07165818061616787,"score_gpt":0.3846393149279286,"score_spread":0.3129811343117608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}