{"id":"W2598864615","doi":"10.1200/jco.2012.30.15_suppl.e13598","title":"Pharmacodynamic evaluation of pCDC2 as the target engagement biomarker to assess activity of MK-1775 a Wee1 tyrosine kinase inhibitor.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Gemcitabine; Wee1; Pharmacodynamics; Pharmacology; Oncology; Chemotherapy; Cisplatin; Biomarker; Tolerability; Internal medicine; Urology; Pharmacokinetics; Cancer; Cyclin-dependent kinase 1; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009630146,0.0003817722,0.0005238406,0.0002849846,0.0001179951,0.0005189078,0.0002753166,0.0003336033,0.00157892],"category_scores_gemma":[0.0009523786,0.00017001,0.0003142791,0.0003315848,0.0002661694,0.0003268687,0.0001618932,0.0008404116,0.0003044455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005966079,"about_ca_system_score_gemma":0.0004292193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983432,"about_ca_topic_score_gemma":0.0008694545,"domain_scores_codex":[0.9996424,0.0001387638,0.00001552966,0.0000585155,0.0001071319,0.00003775981],"domain_scores_gemma":[0.9995849,0.000111622,0.000132631,0.00003705288,0.00005774464,0.00007605462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.09141979,0.009005415,0.06017766,0.0008291798,0.0009521756,0.0002925761,0.0001910773,0.01373066,0.6630231,0.0005440462,0.003038841,0.1567955],"study_design_scores_gemma":[0.00996518,0.2335109,0.1651369,0.00005334371,0.001487852,0.001999622,0.0001820228,0.03787765,0.5327041,0.0004137782,0.01658095,0.00008772407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915234,0.002320942,0.002591784,0.0001382113,0.00003429924,0.0005235513,0.000788739,0.00006653179,0.002012618],"genre_scores_gemma":[0.9972368,0.0002485522,0.001095881,0.00005787376,0.00001499326,0.0001626851,0.0004999901,0.000012545,0.0006705482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00157892,"threshold_uncertainty_score":0.005282044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3902231523669417,"score_gpt":0.585126215296599,"score_spread":0.1949030629296574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}