{"id":"W2598913488","doi":"10.1089/hum.2016.070","title":"Safety and Efficacy of <i>Ex Vivo</i> Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model","year":2017,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Immunosuppression; Lung transplantation; Lung; Ex vivo; Genetic enhancement; Transplantation; Gene delivery; In vivo; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004621425,0.0003769622,0.0003871636,0.0002025637,0.0001253737,0.0003354382,0.0002777181,0.0003447921,0.001072895],"category_scores_gemma":[0.0002003651,0.000110335,0.0003186584,0.00009783615,0.0005001992,0.0003881305,0.0001169527,0.0007239532,0.0001977372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193453,"about_ca_system_score_gemma":0.0002958668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000257619,"about_ca_topic_score_gemma":0.0002856963,"domain_scores_codex":[0.999743,0.00005768382,0.00002672975,0.0000640876,0.00005694766,0.00005147668],"domain_scores_gemma":[0.9997676,0.00004046188,0.00008707785,0.00003865557,0.0000229017,0.00004326519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00327091,0.001331345,0.000596054,0.0001174598,0.00001547015,0.00008478104,0.00004628111,0.0002818754,0.9880342,0.0001205891,0.00009129442,0.006009744],"study_design_scores_gemma":[0.0002458365,0.02589242,0.003828922,0.00001717969,0.00006446608,0.0003453351,0.00005139115,0.001609311,0.9666613,0.00005997466,0.001210961,0.0000129304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942081,0.0007347379,0.003983839,0.00008423864,0.00006587099,0.0001003984,0.0001870005,0.0000692784,0.0005665213],"genre_scores_gemma":[0.9950594,0.000694451,0.002471028,0.00006261603,0.00002214192,0.0001905592,0.0003101453,0.00001432095,0.001175452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072895,"threshold_uncertainty_score":0.003589153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04564386467292615,"score_gpt":0.3469803191819545,"score_spread":0.3013364545090284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}