{"id":"W2598984514","doi":"10.1038/nature21408","title":"LACTB is a tumour suppressor that modulates lipid metabolism and cell state","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health; Ludwig Center at Harvard; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Robertson Foundation; Memorial Sloan-Kettering Cancer Center","keywords":"Lipid metabolism; Cell biology; Mitochondrion; Biology; Phosphatidylethanolamine; Cellular differentiation; Cancer cell; Cell growth; Cell; Cancer research; Cancer; Gene; Biochemistry; Genetics; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007011729,0.0001255268,0.0001279189,0.00002105531,0.000169338,0.00007288898,0.0001865435,0.0007032127,0.00008121992],"category_scores_gemma":[0.00006176067,0.0001044222,0.00005651179,0.00001099033,0.00005906544,0.000006216682,0.0001313651,0.0004646657,0.00001693438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001684991,"about_ca_system_score_gemma":0.0000169483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001273953,"about_ca_topic_score_gemma":0.00001835944,"domain_scores_codex":[0.9993517,0.00003243588,0.00007134012,0.0003007928,0.00007624462,0.0001674708],"domain_scores_gemma":[0.9993755,0.00000593503,0.00008250697,0.0004137342,0.00004800913,0.00007426499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009554147,0.00001702002,0.001154288,0.00001269297,0.00001847754,0.000005724995,0.00007232917,0.000001664951,0.9616315,0.00003800223,0.0364473,0.0005054939],"study_design_scores_gemma":[0.0004932875,0.00003753929,0.007897543,0.000002708261,0.00001451819,0.00001395548,0.000009856814,0.00001721629,0.6758682,0.0001373693,0.3153964,0.0001114438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897471,0.003186495,0.00008470149,0.001322967,0.001272026,0.0001277672,0.0001135783,0.00001234419,0.004132988],"genre_scores_gemma":[0.9868922,0.000488618,0.0004309623,0.001803188,0.0005199566,0.000006200718,0.00004572427,0.00001603807,0.009797081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2857633,"threshold_uncertainty_score":0.542382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008736784160241913,"score_gpt":0.2472770060131761,"score_spread":0.2385402218529342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}