{"id":"W2598984514","doi":"10.1038/nature21408","title":"LACTB is a tumour suppressor that modulates lipid metabolism and cell state","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health; Ludwig Center at Harvard; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Robertson Foundation; Memorial Sloan-Kettering Cancer Center","keywords":"Lipid metabolism; Cell biology; Mitochondrion; Biology; Phosphatidylethanolamine; Cellular differentiation; Cancer cell; Cell growth; Cell; Cancer research; Cancer; Gene; Biochemistry; Genetics; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299846,0.0004244672,0.0002239585,0.0003583224,0.0002694614,0.0004988915,0.0003082126,0.0004088433,0.002244546],"category_scores_gemma":[0.0001613834,0.0001998636,0.0001731788,0.0001907067,0.0004134899,0.0001566898,0.0003524134,0.0007593413,0.0008678102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000569783,"about_ca_system_score_gemma":0.0002010069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006951682,"about_ca_topic_score_gemma":0.0008016293,"domain_scores_codex":[0.9999192,0.00001532405,0.000005271869,0.00001523385,0.00002916562,0.00001584546],"domain_scores_gemma":[0.9998517,0.00002177391,0.00004400385,0.00001210933,0.000008389388,0.00006204649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002998465,0.00002471899,0.0003872976,0.00001464394,0.00000651958,0.000151341,0.00000636394,0.0001002495,0.9965784,0.0002945811,0.0001703403,0.001965778],"study_design_scores_gemma":[0.0001206299,0.0003489413,0.004955796,0.000008897856,0.00002791254,0.001594792,0.000040526,0.002247933,0.9755304,0.0003094997,0.01480047,0.00001419352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829975,0.003917446,0.006404155,0.001079286,0.0001657413,0.00002712899,0.001370764,0.0006954782,0.00334257],"genre_scores_gemma":[0.992993,0.0007941182,0.001227564,0.00009212665,0.00001564798,0.0000249819,0.0009936099,0.00006337795,0.003795705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244546,"threshold_uncertainty_score":0.007508695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008736784160241913,"score_gpt":0.2472770060131761,"score_spread":0.2385402218529342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}