{"id":"W2599002181","doi":"10.2147/dnnd.s71986","title":"Advances in the treatment of relapsing&amp;ndash;remitting multiple sclerosis: the role of pegylated interferon &amp;beta;-1a","year":2017,"lang":"en","type":"review","venue":"Degenerative Neurological and Neuromuscular Disease","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cameco (Canada); Innovation Cluster (Canada); University of Saskatchewan","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada; Saskatchewan Health Research Foundation","keywords":"Multiple sclerosis; Medicine; PEGylation; Neuroinflammation; Pegylated interferon; Neurodegeneration; Interferon beta-1b; Immunology; Clinical trial; Pharmacology; Disease; Internal medicine; Interferon beta; Polyethylene glycol; Ribavirin; Biology; Hepatitis C virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006587769,0.0005507258,0.00109845,0.002250147,0.000236647,0.0006707413,0.0005687843,0.0008326735,0.003321751],"category_scores_gemma":[0.0009076133,0.0001649226,0.0006906195,0.001786223,0.0003362419,0.000905799,0.0004771206,0.001367156,0.0009727385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412252,"about_ca_system_score_gemma":0.0009708021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034686,"about_ca_topic_score_gemma":0.001788837,"domain_scores_codex":[0.9997749,0.00004803087,0.00005373362,0.00003591985,0.00007135786,0.0000160008],"domain_scores_gemma":[0.9995611,0.0002536932,0.0000659362,0.00001099168,0.00008405147,0.00002423288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001037982,0.0000675116,0.0001669724,0.03389996,0.000135358,0.0001233442,0.00005910229,0.000189112,0.0009971153,0.002000263,0.01154281,0.9507145],"study_design_scores_gemma":[0.00004084871,0.000176294,0.001501202,0.01462188,0.0004618666,0.001693086,0.00009847662,0.00009762235,0.0006799551,0.001714032,0.9788937,0.00002095261],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008588396,0.9993424,0.0000415566,0.0001422512,0.00005296039,0.000002342242,0.000009506058,0.000002860073,0.0003202119],"genre_scores_gemma":[0.0006133685,0.9989875,0.0001009607,0.00009724252,0.00005263886,0.000003420756,0.00001258915,7.079321e-7,0.0001314559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003321751,"threshold_uncertainty_score":0.01111233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2259848205252486,"score_gpt":0.3864206091049136,"score_spread":0.160435788579665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}