{"id":"W2599002181","doi":"10.2147/dnnd.s71986","title":"Advances in the treatment of relapsing&amp;ndash;remitting multiple sclerosis: the role of pegylated interferon &amp;beta;-1a","year":2017,"lang":"en","type":"review","venue":"Degenerative Neurological and Neuromuscular Disease","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cameco (Canada); Innovation Cluster (Canada); University of Saskatchewan","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada; Saskatchewan Health Research Foundation","keywords":"Multiple sclerosis; Medicine; PEGylation; Neuroinflammation; Pegylated interferon; Neurodegeneration; Interferon beta-1b; Immunology; Clinical trial; Pharmacology; Disease; Internal medicine; Interferon beta; Polyethylene glycol; Ribavirin; Biology; Hepatitis C virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004414288,0.0006260538,0.001970151,0.0001584297,0.0003707229,0.000054787,0.0005066623,0.0001707646,0.00002336969],"category_scores_gemma":[0.001824032,0.0002742448,0.0008616744,0.000268519,0.0009381993,0.0000931976,0.0002419034,0.000593719,0.000006433015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002966184,"about_ca_system_score_gemma":0.0001051499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000244125,"about_ca_topic_score_gemma":0.00006525791,"domain_scores_codex":[0.9953178,0.001937321,0.0008713739,0.0008372967,0.0005858137,0.0004503978],"domain_scores_gemma":[0.9965016,0.001437492,0.0005933678,0.001089977,0.0001514513,0.0002261771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008579412,0.001424093,0.003914938,0.002388079,0.0002254316,0.0000651991,0.0004685531,0.00001302557,0.0004462235,0.00003254286,0.00005497512,0.990109],"study_design_scores_gemma":[0.001164355,0.002077954,0.01857174,0.003334451,0.001204424,0.0000158694,0.00003348495,0.0001804972,0.0000433435,0.00002542183,0.9730749,0.0002736029],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06097403,0.9358966,0.00000640909,0.0003989119,0.00008550099,0.002332849,0.0001750757,0.00002138728,0.0001091948],"genre_scores_gemma":[0.05484866,0.9441502,0.00004819228,0.0001126345,0.000139344,0.0005102535,0.000104148,0.00003729365,0.0000492743],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9898354,"threshold_uncertainty_score":0.999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2259848205252486,"score_gpt":0.3864206091049136,"score_spread":0.160435788579665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}